Review

Research advances in transcription factor AP-2 in embryonic and cardiovascular development
 

  • WANG Jing ,
  • LI Fen
Expand
  • Department of Pediatric Cardiology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

Online published: 2016-11-29

Supported by

National Natural Science Foundation of China, 81170152

Abstract

Transcription factor AP-2 plays an important role in embryonic and cardiovascular development and often influences the development of embryo. AP-2α and AP-2β are associated with the development of cardiovascular system. AP-2α mainly affects ventricular outflow tract and arteries, while AP-2β has been identified to be involved in the opening and closing of ductus arterious. This paper systematically reviews latest research advances in the structure and expression of AP-2 gene family, as well as its functions and mechanisms in embryonic and cardiovascular development, especially in patent ductus arterious.

Cite this article

WANG Jing , LI Fen .

Research advances in transcription factor AP-2 in embryonic and cardiovascular development
 
[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2016 , 36(11) : 1658 . DOI: 10.3969/j.issn.1674-8115.2016.11.024

Outlines

/