Original article (Clinical research)

Clinical efficacy of intravitreal injection of Conbercept in treatment of diabetic macular edema

  • SUN Qing-lei ,
  • YAN Yan ,
  • ZHU Li-na ,
  • QIN Xiao-ling ,
  • TAN Ye ,
  • LIU Jie ,
  • TAN Hai-bo ,
  • NING Li ,
  • LIU Lin
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  • 1. Department of Ophthalmology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; 2. Department of Ophthalmology, Lujiazui Community Health Service Center, Shanghai 200120, China; 3. Department of Ophthalmology, Gongli Hospital, Shanghai 200135, China; 4. Department of Ophthalmology, Weifang Community Health Center, Shanghai 200122, China

Online published: 2017-05-31

Supported by

Science and Technology Project of Health Bureau of Pudong New Area, Shanghai, PW2013D-1; Project of Shanghai Municipal Commission of Health and Family Planning General, M20140513

Abstract

Objective · To investigate the clinical effect of intravitreal injection of Conbercept in the treatment of diabetic macular edema (DME). Methods · Eleven patients (17 eyes) with DME (inflammatory type) received intravitreal injection of Conbercept monthly. After the first treatment, the patients were treated on demand. Follow-up after treatment for more than 6 months, the best corrected visual acuity (BCVA), central retinal thickness (CRT), diminished rate of DME and result of fundus fluorescein angiography(FFA) of DME eyes before and after treatment were compared. Results · During a follow-up of 7-29 months [(12±7) months], the injections were given 1-10 times [(4±3) times]. The results showed that the treatment effects on improving BCVA (logMAR) and diminishing of CRT were significant (t=7.306, P=0.001; t=5.272, P=0.000). The diminished rate of DME of our patients was 76.5%. Conclusion · Intravitreal injection of Conbercept in the treatment of DME is effective on reducing macular edema and improving visual acuity.

Cite this article

SUN Qing-lei , YAN Yan , ZHU Li-na , QIN Xiao-ling , TAN Ye , LIU Jie , TAN Hai-bo , NING Li , LIU Lin . Clinical efficacy of intravitreal injection of Conbercept in treatment of diabetic macular edema[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2017 , 37(5) : 652 . DOI: 10.3969/j.issn.1674-8115.2017.05.016

Outlines

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