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Clinical efficacy of intravitreal injection of Conbercept in treatment of diabetic macular edema

SUN Qing-lei1, YAN Yan1, ZHU Li-na1, QIN Xiao-ling2, TAN Ye3, LIU Jie4, TAN Hai-bo1, NING Li1, LIU Lin1   

  1. 1. Department of Ophthalmology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; 2. Department of Ophthalmology, Lujiazui Community Health Service Center, Shanghai 200120, China; 3. Department of Ophthalmology, Gongli Hospital, Shanghai 200135, China; 4. Department of Ophthalmology, Weifang Community Health Center, Shanghai 200122, China

  • Online:2017-05-28 Published:2017-05-31
  • Supported by:

    Science and Technology Project of Health Bureau of Pudong New Area, Shanghai, PW2013D-1; Project of Shanghai Municipal Commission of Health and Family Planning General, M20140513

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Abstract:

Objective · To investigate the clinical effect of intravitreal injection of Conbercept in the treatment of diabetic macular edema (DME). Methods · Eleven patients (17 eyes) with DME (inflammatory type) received intravitreal injection of Conbercept monthly. After the first treatment, the patients were treated on demand. Follow-up after treatment for more than 6 months, the best corrected visual acuity (BCVA), central retinal thickness (CRT), diminished rate of DME and result of fundus fluorescein angiography(FFA) of DME eyes before and after treatment were compared. Results · During a follow-up of 7-29 months [(12±7) months], the injections were given 1-10 times [(4±3) times]. The results showed that the treatment effects on improving BCVA (logMAR) and diminishing of CRT were significant (t=7.306, P=0.001; t=5.272, P=0.000). The diminished rate of DME of our patients was 76.5%. Conclusion · Intravitreal injection of Conbercept in the treatment of DME is effective on reducing macular edema and improving visual acuity.

Key words: diabetic macular edema, Conbercept, the best corrected visual acuity, central retinal thickness