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Molecular mechanism for telomere-binding proteins in regulating mammalian spermatogenesis

  • HUANG Chen-hui ,
  • LEI Ming
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  • HUANG Chen-hui, LEI Ming

Online published: 2018-05-03

Supported by

National Basic Research Program of China, 2013CB910402; National Natural Science Foundation of China, 31330040, 31525007, 31500625; Strategic Priority Research Program of the Chinese Academy of Sciences, XDB08010201; Outstanding Academic Leader Program of Science and Technology Commission of Shanghai Municipality, 16XD1405000

Abstract

Telomere attachment to the nuclear envelope and telomere-led chromosomal movement allow proper homologous pairing in mammalian
meiotic prophase I. However, the molecular mechanisms for telomere meiosis-specific functions remain to be elucidated. The present review introduced
the structure basis for telomere attachment to the nuclear envelope, and revealed a new mechanism by which telomere functions in mammalian
spermatogenesis.

Cite this article

HUANG Chen-hui , LEI Ming . Molecular mechanism for telomere-binding proteins in regulating mammalian spermatogenesis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2018 , 38(3) : 241 . DOI: 10.3969/j.issn.1674-8115.2018.03.001

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