Review

Role of phosphoglycerate mutase 1 in the occurence and development of tumor

  • LIANG Qian1 ,
  • 2 ,
  • SHEN Ying1 ,
  • 2
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  • 1. Department of Pharmacology and Chemical Biology, 2. Shanghai Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School ofMedicine, Shanghai 200025, China

Online published: 2018-05-03

Supported by

National Natural Science Foundation of China, 81473232, 81773748; Project of Shanghai Municipal Commission of Health and Family Planning, 201440576; Foundation ofShanghai Jiao Tong University School of Medicine, 14XJ10002

Abstract

Phosphoglycerate mutase 1 (PGAM1) as one of the most important enzymes for glycolysis pathway, is highly expressed in multipletumor tissues and negatively correlated with the prognosis of cancer patients. PGAM1 catalyzes the conversion of 3-phosphoglycerate (3-PG) to2-phosphoglycerate (2-PG) in glycolysis pathway, then promoting anabolic pathways, energy generation, and maintaining redox balance during cancercell proliferation and metastasis. The small molecule PGAM1 inhibitors have emerged as a promising strategy for anti-tumor therapy. In this review, the significance of PGAM1 in tumor was reviewed and the research progress of PGAM1 inhibitors was also introduced.

Cite this article

LIANG Qian1 , 2 , SHEN Ying1 , 2 . Role of phosphoglycerate mutase 1 in the occurence and development of tumor[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2018 , 38(4) : 463 . DOI: 10.3969/j.issn.1674-8115.2018.04.021

Outlines

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