BV8, a lately defined secreted protein, is proved to play an important role in the angiogenesis process of endocrine, cardiovascular system, kidney and other organs. Moreover, it contributes to the CD11b+Gr1+ myeloid cell-dependent tumor neo-vascularization. Meanwhile, anti-BV8 antibodytherapy has been shown to be against solid tumors via inhibition of angiogenesis in animal models. This review systematically introduced the currentknowledge on BV8 structure to function, mechanism to its role in diseases. Consequently, this review will probably provide new ideas anddirection to the new target of the current anti-vascular therapy for cancer and to the future investigation.