In recent years, with the development of Chinas reform of medical and health services, the level of clinical medicine in China has been greatly improved, but there is still a big gap between China and developed countries in Europe and America. China has a large population and rich and diverse clinical resources. However, innovative research and results in key guidelines, diagnosis and treatment programs, and major innovative drugs in the diagnosis and treatment of diseases are insufficient. The key reason is the lack of effective integration of clinical resources. Taking Shanghai Jiao Tong University School of Medicine as an example, under the background of “double first-class” construction, this paper summarized the status quo of clinical resource integration, analyzed the key issues in integration, and tried to put forward the strategies of medical, scientific research, and talent integration in clinical resource integration, to provide path for promoting clinical resource integration and clinical discipline construction.