Objective · To study the impact of depression on tobacco among adolescents in Shanghai, and to provide reference for the development of effective youth tobacco control measures. Methods · A stratified random cluster sampling method was used to extract 10 557 middle school students in Shanghai. The survey was conducted using the Global Youth Tobacco Questionnaire (WHO) and the Patient Health Questionnaire 2-Item Chinese Version (PHQ-2). Results · Among the respondents, the incidence of depression motion was 12.4%. Both the current smoking rate (8.0% vs 2.5%) and future smoking intention (14.2% vs 4.6%) among students with depression were higher than those without depression (P0.000). Compared with those without depression, the risks of current smoking and future smoking intention among youth with depression were 1.56 times (95% CI 1.16-2.10) and 1.92 times (95% CI 1.54-2.40) respectively. In addition, the risk of smoking behavior was higher among female with depression than male students, as well as junior high school students than senior high school students. Conclusion · Depression is one of the influencing factors of tobacco in adolescents. Schools and society should attach importance to the mental health maintenance of adolescents, carry out school-based preventive measures actively, and pay attention to high-risk groups such as female and junior school students with depression particularly.