Journal of Shanghai Jiao Tong University (Medical Science) >

2020 , Vol. 40 >Issue 1: 118

DOI: https://doi.org/10.3969/j.issn.1674-8115.2020.01.019

Review

Research progress of the mechanism and treatment of macrophage in spinal cord injury repair

  • LIN Jun-qing ,
  • ZHENG Xian-you ,
  • BAO Bing-bo ,
  • LI Xing-wei ,
  • GAO Tao ,
  • HUANG Teng-li
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  • Department of Orthopaedic Surgery, Shanghai Sixth Peoples Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

Online published: 2020-03-05

Supported by

National Natural Science Foundation of China (81974331, 81672144).

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Abstract

Self-repair has been initiated after spinal cord injury (SCI). Unlike wound healing, the self-regeneration of spinal cord is incomplete and insufficient. Many studies show that there are a lot of cells and factors active in self-repair of SCI. Inflammatory is a hard problem for us to face in SCI. Over-inflammatory will casecondary damage to the spinal cord and the capacity of self-repair. In the inflammatory environment, Many kinds of research evidence prove that macrophage pays a vital role in the over inflammatory with damaging the self-repair of SCI. Thus, targeting macrophage in spinal cord injury will hopefully become a method in SCI repair. This review clarifies the function and mechanism of macrophage in SCI repair and the new targeting macrophage methods in recovering the self-repair capacity of SCI.

Key words： spinal cord injury; macrophage; self-repair; neuroregenerations; therapy

Cite this article

LIN Jun-qing , ZHENG Xian-you , BAO Bing-bo , LI Xing-wei , GAO Tao , HUANG Teng-li . Research progress of the mechanism and treatment of macrophage in spinal cord injury repair[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2020 , 40(1) : 118 . DOI: 10.3969/j.issn.1674-8115.2020.01.019

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