›› 2020, Vol. 40 ›› Issue (1): 118-.doi: 10.3969/j.issn.1674-8115.2020.01.019

• Review • Previous Articles     Next Articles

Research progress of the mechanism and treatment of macrophage in spinal cord injury repair

LIN Jun-qing, ZHENG Xian-you, BAO Bing-bo, LI Xing-wei, GAO Tao, HUANG Teng-li   

  1. Department of Orthopaedic Surgery, Shanghai Sixth Peoples Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2020-01-28 Published:2020-03-05
  • Supported by:
    National Natural Science Foundation of China (81974331, 81672144).

Abstract: Self-repair has been initiated after spinal cord injury (SCI). Unlike wound healing, the self-regeneration of spinal cord is incomplete and insufficient. Many studies show that there are a lot of cells and factors active in self-repair of SCI. Inflammatory is a hard problem for us to face in SCI. Over-inflammatory will casecondary damage to the spinal cord and the capacity of self-repair. In the inflammatory environment, Many kinds of research evidence prove that macrophage pays a vital role in the over inflammatory with damaging the self-repair of SCI. Thus, targeting macrophage in spinal cord injury will hopefully become a method in SCI repair. This review clarifies the function and mechanism of macrophage in SCI repair and the new targeting macrophage methods in recovering the self-repair capacity of SCI.

Key words: spinal cord injury, macrophage, self-repair, neuroregenerations, therapy