Journal of Shanghai Jiao Tong University (Medical Science) >

2021 , Vol. 41 >Issue 2: 233 - 240

DOI: https://doi.org/10.3969/j.issn.1674-8115.2021.02.017

Review

Application of proteomics to the study of gynecological diseases

  • Yuan-xin HUANG ,
  • Dong-mei LAI
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  • Shanghai Key Laboratory of Embryo Original Diseases, The International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China

Received date: 2020-07-30

  Online published: 2021-02-28

Supported by

National Key Research and Development Project of China(2018YFC1004800);National Natural Science Foundation of China(81971334);Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20152236)

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Abstract

At present, proteomics is one of the core contents of biomedical research. Its research includes the exploration of biological processes such as signal transduction, cell proliferation and differentiation, protein translation and modification, as well as the search for biomarkers and drug targets of diseases. This review summarizes the application of mass spectrometry-based proteomics to the studies of pathogenesis and biomarkers of common gynecological diseases, including polycystic ovary syndrome, premature ovarian insufficiency, ovarian cancer, endometrial cancer and cervical cancer.

Key words： proteomics; polycystic ovary syndrome; premature ovarian insufficiency; ovarian cancer; endometrial cancer; cervical cancer

Cite this article

Yuan-xin HUANG , Dong-mei LAI . Application of proteomics to the study of gynecological diseases[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2021 , 41(2) : 233 -240 . DOI: 10.3969/j.issn.1674-8115.2021.02.017

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