Application of proteomics to the study of gynecological diseases

doi:10.3969/j.issn.1674-8115.2021.02.017

Abstract

Abstract:

At present, proteomics is one of the core contents of biomedical research. Its research includes the exploration of biological processes such as signal transduction, cell proliferation and differentiation, protein translation and modification, as well as the search for biomarkers and drug targets of diseases. This review summarizes the application of mass spectrometry-based proteomics to the studies of pathogenesis and biomarkers of common gynecological diseases, including polycystic ovary syndrome, premature ovarian insufficiency, ovarian cancer, endometrial cancer and cervical cancer.

Key words: proteomics, polycystic ovary syndrome, premature ovarian insufficiency, ovarian cancer, endometrial cancer, cervical cancer

CLC Number:

R711.7

Yuan-xin HUANG, Dong-mei LAI. Application of proteomics to the study of gynecological diseases[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(2): 233-240.

Figures/Tables 5

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References 37

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Disease	Sample	Biomarker	Molecular function	Reference
PCOS	Ovarian follicle	Alpha-1-antitrypsin，SERPINA1	Protease inhibitor	[8]
		Inter-alpha-trypsin inhibitor heavy chain 4, ITIH4	Protease inhibitor	[8]
		Mitogen-activated protein kinase kinase 4, MAPKK4	Signal transduction	[9]
	Plasma	Apolipoprotein C3, APOC3	Lipid metabolism	[11]
		Serotransferrin	Iron metabolism	[11]
		Complement C3	Complement activation	[11]
		Properdin	Complement activation	[13]
		Insulin-like growth factor II	Growth factor	[13]

Disease	Sample	Biomarker	Molecular function	Reference
PCOS	Ovarian follicle	Alpha-1-antitrypsin，SERPINA1	Protease inhibitor	[8]
		Inter-alpha-trypsin inhibitor heavy chain 4, ITIH4	Protease inhibitor	[8]
		Mitogen-activated protein kinase kinase 4, MAPKK4	Signal transduction	[9]
	Plasma	Apolipoprotein C3, APOC3	Lipid metabolism	[11]
		Serotransferrin	Iron metabolism	[11]
		Complement C3	Complement activation	[11]
		Properdin	Complement activation	[13]
		Insulin-like growth factor II	Growth factor	[13]

Disease	Sample	Biomarker	Molecular function	Reference
POI	Ovarian follicle	Humanepididymisprotein 4,HE4/WFDC2	Protease inhibitor	[15]
		Reticulocalbin-1/-3, RCN1/RCN3	Calcium-binding protein	[16]
		Heterogeneous nuclear ribonucleoprotein K, HNRNPK	RNA binding protein	[16]
		Actin	Cytoskeleton component	[16]
		Major vault protein, MVP	Nucleo-cytoplasmic transport	[16]
	Plasma	Ceruloplasmin	Copper binding protein	[17]
		Complement C3	Complement activation	[17]
		Fibrinogen α/β	Blood coagulation	[17]
		Sex hormone-binding globulin, SHBG	Steroid binding protein	[17]

Disease	Sample	Biomarker	Molecular function	Reference
POI	Ovarian follicle	Humanepididymisprotein 4,HE4/WFDC2	Protease inhibitor	[15]
		Reticulocalbin-1/-3, RCN1/RCN3	Calcium-binding protein	[16]
		Heterogeneous nuclear ribonucleoprotein K, HNRNPK	RNA binding protein	[16]
		Actin	Cytoskeleton component	[16]
		Major vault protein, MVP	Nucleo-cytoplasmic transport	[16]
	Plasma	Ceruloplasmin	Copper binding protein	[17]
		Complement C3	Complement activation	[17]
		Fibrinogen α/β	Blood coagulation	[17]
		Sex hormone-binding globulin, SHBG	Steroid binding protein	[17]

Disease	Sample	Biomarker	Molecular function	Reference
Ovarian cancer	Tumor tissue	Phosphoglucomutase 1, PGM1	Glycogen metabolism	[21]
		Nicotinamide N-methyltransferase, NNMT	N-methylation	[22]
		Cancer/testis antigen 45, CT45	-	[24]
		Thioredoxin domain-containing protein 17, TXNDC17	-	[25]