JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (2): 228-232.doi: 10.3969/j.issn.1674-8115.2021.02.016

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Progress and prospect of in situ bioprinting

Wen-tao LI(), Jin-wu WANG()   

  1. Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Received:2020-02-26 Online:2021-02-28 Published:2021-02-28
  • Contact: Jin-wu WANG;
  • Supported by:
    National Key Research and Development Program of China(2018YFB1105600);National Natural Science Foundation of China(81572156);Project of Science and Technology Commission of Shanghai Municipality(19XD1434200);Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20152224)


Bioprinting is a new biological manufacturing technology, which opens up new ways for regenerative therapy. The purpose of bioprinting is to create the internal plants in vitro. However, it is difficult to culture and vascularize printed tissue in vitro. In order to overcome this difficulty, in situ printing is presented to print the tissue directly on the injured or defective site, using the natural microenvironment in vivo to make the printed tissue mature. This article reviews the technology, advantages and research status of in situ bioprinting and briefly introduces the future direction of in situ bioprinting.

Key words: in situ bioprinting, tissue regeneration, bioink

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