Progress and prospect of in situ bioprinting

doi:10.3969/j.issn.1674-8115.2021.02.016

JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (2): 228-232.doi: 10.3969/j.issn.1674-8115.2021.02.016

• Review • Previous Articles Next Articles

Progress and prospect of in situ bioprinting

Wen-tao LI(), Jin-wu WANG()

Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

Received:2020-02-26 Online:2021-02-28 Published:2021-02-28
Contact: Jin-wu WANG E-mail:li_wentao@sjtu.edu.cn;Jinwu_wang@163.com
Supported by:
National Key Research and Development Program of China(2018YFB1105600);National Natural Science Foundation of China(81572156);Project of Science and Technology Commission of Shanghai Municipality(19XD1434200);Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20152224)

Abstract

Abstract:

Bioprinting is a new biological manufacturing technology, which opens up new ways for regenerative therapy. The purpose of bioprinting is to create the internal plants in vitro. However, it is difficult to culture and vascularize printed tissue in vitro. In order to overcome this difficulty, in situ printing is presented to print the tissue directly on the injured or defective site, using the natural microenvironment in vivo to make the printed tissue mature. This article reviews the technology, advantages and research status of in situ bioprinting and briefly introduces the future direction of in situ bioprinting.

Key words: in situ bioprinting, tissue regeneration, bioink

CLC Number:

Q819

Wen-tao LI, Jin-wu WANG. Progress and prospect of in situ bioprinting[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(2): 228-232.

TrendMD

References 37

1	Murphy SV, Atala A. 3D bioprinting of tissues and organs [J]. Nat Biotechnol, 2014, 32(8): 773-785.
2	Zhang YS, Yue K, Aleman J, et al. 3D bioprinting for tissue and organ fabrication[J]. Ann Biomed Eng, 2017, 45(1): 148-163.
3	Ozbolat IT. Bioprinting scale-up tissue and organ constructs for transplantation[J]. Trends Biotechnol, 2015, 33(7): 395-400.
4	Campbell PG, Weiss LE. Tissue engineering with the aid of inkjet printers[J]. Expert Opin Biol Ther, 2007, 7(8): 1123-1127.
5	Ashammakhi N, Ahadian S, Pountos I, et al. In situ three-dimensional printing for reparative and regenerative therapy[J]. Biomed Microdevices, 2019, 21(2): 42.
6	Wang MY, He JK, Liu YX, et al. The trend towards in vivo bioprinting[J]. Int J Bioprinting, 2015, 1(1): 15-26.
7	Singh S, Choudhury D, Yu F, et al. In situ-bioprinting:bioprinting from benchside to bedside?[J]. Acta Biomater, 2020, 101: 14-25.
8	Gudapati H, Dey M, Ozbolat I. A comprehensive review on droplet-based bioprinting: past, present and future[J]. Biomaterials, 2016, 102: 20-42.
9	Ozbolat IT, Hospodiuk M. Current advances and future perspectives in extrusion-based bioprinting[J]. Biomaterials, 2016, 76: 321-343.
10	Sorkio A, Koch L, Koivusalo L, et al. Human stem cell based corneal tissue mimicking structures using laser-assisted 3D bioprinting and functional bioinks[J]. Biomaterials, 2018, 171: 57-71.
11	Keriquel V, Guillemot F, Arnault I, et al. In vivo bioprinting for computer-and robotic-assisted medical intervention: preliminary study in mice[J]. Biofabrication, 2010, 2(1): 014101.
12	Cohen DL, Lipton JI, Bonassar LJ, et al. Additive manufacturing for in situ repair of osteochondral defects[J]. Biofabrication, 2010, 2(3): 035004.
13	Keriquel V, Oliveira H, Rémy M, et al. In situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications[J]. Sci Rep, 2017, 7(1): 1778.
14	Albanna M, Binder KW, Murphy SV, et al. In situ bioprinting of autologous skin cells accelerates wound healing of extensive excisional full-thickness wounds[J]. Sci Rep, 2019, 9(1): 1856.
15	Lipskas J, Deep K, Yao W. Robotic-assisted 3D bio-printing for repairing bone and cartilage defects through a minimally invasive approach[J]. Sci Rep, 2019, 9(1): 3746.
16	Ding HZ, Chang RC. Simulating image-guided in situ bioprinting of a skin graft onto a phantom burn wound bed[J]. Addit Manuf, 2018, 22: 708-719.
17	O'Connell CD, Di Bella C, Thompson F, et al. Development of the Biopen: a handheld device for surgical printing of adipose stem cells at a chondral wound site[J]. Biofabrication, 2016, 8(1): 015019.
18	Murdock MH, Badylak SF. Biomaterials-based in situ tissue engineering[J]. Curr Opin Biomed Eng, 2017, 1: 4-7.
19	Hakimi N, Cheng R, Leng L, et al. Handheld skin printer: in situ formation of planar biomaterials and tissues[J]. Lab Chip, 2018, 18(10): 1440-1451.
20	Binder KW, Zhao WX, Aboushwareb T, et al. In situ bioprinting of the skin for burns[J]. J Am Coll Surg, 2010, 211(3): S76.
21	Sofokleous P, Stride E, Bonfield W, et al. Design, construction and performance of a portable handheld electrohydrodynamic multi-needle spray gun for biomedical applications[J]. Mater Sci Eng C Mater Biol Appl, 2013, 33(1): 213-223.
22	Makris EA, Gomoll AH, Malizos KN, et al. Repair and tissue engineering techniques for articular cartilage[J]. Nat Rev Rheumatol, 2015, 11(1): 21-34.
23	Duchi S, Onofrillo C, O'Connell CD, et al. Handheld co-axial bioprinting: application to in situ surgical cartilage repair[J]. Sci Rep, 2017, 7(1): 5837.
24	Di Bella C, Duchi S, O'Connell CD, et al. In situ handheld three-dimensional bioprinting for cartilage regeneration[J]. J Tissue Eng Regen Med, 2018, 12(3): 611-621.
25	Duchi S, Onofrillo C, O'Connell CD, et al. Innovative cartilage regeneration for in situ co-axial 3D bioprinting [J]. Tissue Engineering Part A, 2017, 23: S22.
26	Ibrahim A. 3D bioprinting bone[M]//Thomas DJ.3D bioprinting for reconstructive surgery.Duxford: Elsevier, 2018: 245-275.
27	Kérourédan O, Hakobyan D, Rémy M, et al. In situ prevascularization designed by laser-assisted bioprinting: effect on bone regeneration[J]. Biofabrication, 2019, 11(4): 045002.
28	Li L, Yu F, Shi JP, et al. In situ repair of bone and cartilage defects using 3D scanning and 3D printing[J]. Sci Rep, 2017, 7(1): 9416.
29	Jin C, Zhang J, Li XK, et al. Injectable 3-D fabrication of medical electronics at the target biological tissues[J]. Sci Rep, 2013, 3: 3442.
30	Sun XY, Yuan B, Rao W, et al. Amorphous liquid metal electrodes enabled conformable electrochemical therapy of tumors[J]. Biomaterials, 2017, 146: 156-167.
31	Li C, Faulkner-Jones A, Dun AR, et al. Rapid formation of a supramolecular polypeptide-DNA hydrogel for in situ three-dimensional multilayer bioprinting[J]. Angew Chem Int Ed Engl, 2015, 54(13): 3957-3961.
32	Li YC, Zhang YS, Akpek A, et al. 4D bioprinting: the next-generation technology for biofabrication enabled by stimuli-responsive materials[J]. Biofabrication, 2016, 9(1): 012001.
33	Ashammakhi N, Ahadian S, Fan ZJ, et al. Advances and future perspectives in 4D bioprinting[J]. Biotechnol J, 2018, 13(12): e1800148.
34	Kahn JS, Hu YW, Willner I. Stimuli-responsive DNA-based hydrogels: from basic principles to applications[J]. Acc Chem Res, 2017, 50(4): 680-690.
35	Ozbolat IT, Moncal KK, Gudapati H. Evaluation of bioprinter technologies[J]. Addit Manuf, 2017, 13: 179-200.
36	Zhu ZJ, Guo SZ, Hirdler T, et al. 3D printing: 3D printed functional and biological materials on moving freeform surfaces (adv. Mater. 23/2018)[J]. Adv Mater, 2018, 30(23): 1870165.
37	Evans CH. Gene delivery to bone[J]. Adv Drug Deliv Rev, 2012, 64(12): 1331-1340.

Progress and prospect of in situ bioprinting

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

TrendMD

References 37

Related Articles 1

Recommended Articles

Metrics

Comments