Research advances in inflammatory mechanism of anhedonia

doi:10.3969/j.issn.1674-8115.2021.02.018

Abstract

Abstract:

Anhedonia, a typical symptom of many mental diseases, is also an important indicator for treatment outcome. Further exploration of the mechanism of anhedonia and clear definition and illustration of its pathophysiological basis are helpful to the diagnosis and treatment of related diseases. In recent years, converging evidence has implicated that inflammation-driven alterations in kynurenine pathway (KP) and tetrahydrobiopterin (BH4) metabolism lead to nerve injury and disturbance of neurotransmitter in reward circuit, which is closely related to the emergence and development of anhedonia. Therefore, this review aims to summarize the research advances in the inflammatory mechanism of anhedonia, with the emphasis on both KP and BH4 metabolism.

Key words: anhedonia, reward circuit, inflammation, kynurenine pathway, tetrahydrobiopterin

CLC Number:

Ze-nan WU, Chen ZHANG. Research advances in inflammatory mechanism of anhedonia[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(2): 241-245.

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References 39

1	Kendler KS. The phenomenology of major depression and the representativeness and nature of DSM criteria[J]. Am J Psychiatry, 2016, 173(8): 771-780.
2	Bennik EC, Nederhof E, Ormel J, et al. Anhedonia and depressed mood in adolescence: course, stability, and reciprocal relation in the TRAILS study[J]. Eur Child Adolesc Psychiatry, 2014, 23(7): 579-586.
3	Winer ES, Nadorff MR, Ellis TE, et al. Anhedonia predicts suicidal ideation in a large psychiatric inpatient sample[J]. Psychiatry Res, 2014, 218(1-2): 124-128.
4	Barch DM, Whalen D, Gilbert K, et al. Neural indicators of anhedonia: predictors and mechanisms of treatment change in a randomized clinical trial in early childhood depression[J]. Biol Psychiatry, 2019, 85(10): 863-871.
5	Felger JC, Li Z, Haroon E, et al. Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression[J]. Mol Psychiatry, 2016, 21(10): 1358-1365.
6	Boyle CC, Kuhlman KR, Dooley LN, et al. Inflammation and dimensions of reward processing following exposure to the influenza vaccine[J]. Psychoneuroendocrinology, 2019, 102: 16-23.
7	Murakami Y, Ishibashi T, Tomita E, et al. Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2, 3-dioxygenase 1[J]. Sci Rep, 2016, 6: 29920.
8	Bergamini G, Mechtersheimer J, Azzinnari D, et al. Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice[J]. Neurobiol Stress, 2018, 8: 42-56.
9	Rømer Thomsen K, Whybrow PC, Kringelbach ML. Reconceptualizing anhedonia: novel perspectives on balancing the pleasure networks in the human brain[J]. Front Behav Neurosci, 2015, 9: 49.
10	Zhang B, Lin P, Shi HQ, et al. Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis[J]. Brain Imaging Behav, 2016, 10(3): 920-939.
11	Freed RD, Mehra LM, Laor D, et al. Anhedonia as a clinical correlate of inflammation in adolescents across psychiatric conditions[J]. World J Biol Psychiatry, 2019, 20(9): 712-722.
12	Szczypiński JJ, Gola M. Dopamine dysregulation hypothesis: the common basis for motivational anhedonia in major depressive disorder and schizophrenia?[J]. Rev Neurosci, 2018, 29(7): 727-744.
13	Wenzel JM, Cheer JF. Endocannabinoid regulation of reward and reinforcement through interaction with dopamine and endogenous opioid signaling[J]. Neuropsychopharmacology, 2018, 43(1): 103-115.
14	Yan C, Yang T, Yu QJ, et al. Rostral medial prefrontal dysfunctions and consummatory pleasure in schizophrenia: a meta-analysis of functional imaging studies[J]. Psychiatry Res, 2015, 231(3): 187-196.
15	Der-Avakian A, D'Souza MS, Potter DN, et al. Social defeat disrupts reward learning and potentiates striatal nociceptin/orphanin FQ mRNA in rats[J]. Psychopharmacology (Berl), 2017, 234(9-10): 1603-1614.
16	Yin LJ, Xu XD, Chen G, et al. Inflammation and decreased functional connectivity in a widely-distributed network in depression: centralized effects in the ventral medial prefrontal cortex[J]. Brain Behav Immun, 2019, 80: 657-666.
17	Felger JC, Mun J, Kimmel HL, et al. Chronic interferon-α decreases dopamine 2 receptor binding and striatal dopamine release in association with anhedonia-like behavior in nonhuman primates[J]. Neuropsychopharmacology, 2013, 38(11): 2179-2187.
18	Felger JC, Hernandez CR, Miller AH. Levodopa reverses cytokine-induced reductions in striatal dopamine release[J]. Int J Neuropsychopharmacol, 2015, 18(4): pyu084.
19	Kim H, Chen L, Lim G, et al. Brain indoleamine 2, 3-dioxygenase contributes to the comorbidity of pain and depression[J]. J Clin Invest, 2012, 122(8): 2940-2954.
20	Salazar F, Hall L, Negm OH, et al. The mannose receptor negatively modulates the Toll-like receptor 4-aryl hydrocarbon receptor-indoleamine 2, 3-dioxygenase axis in dendritic cells affecting T helper cell polarization[J]. J Allergy Clin Immunol, 2016, 137(6): 1841-1851.e2.
21	Rodrigues FTS, de Souza MRM, Lima CNC, et al. Major depression model induced by repeated and intermittent lipopolysaccharide administration: long-lasting behavioral, neuroimmune and neuroprogressive alterations[J]. J Psychiatr Res, 2018, 107: 57-67.
22	Xie W, Cai L, Yu YH, et al. Activation of brain indoleamine 2, 3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy[J]. J Neuroinflammation, 2014, 11: 41.
23	Walker AK, Budac DP, Bisulco S, et al. NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice[J]. Neuropsychopharmacology, 2013, 38(9): 1609-1616.
24	Laumet G, Zhou WJ, Dantzer R, et al. Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain[J]. Brain Behav Immun, 2017, 66: 94-102.
25	Schwarz MJ, Guillemin GJ, Teipel SJ, et al. Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls[J]. Eur Arch Psychiatry Clin Neurosci, 2013, 263(4): 345-352.
26	Monteggia LM, Gideons E, Kavalali ET. The role of eukaryotic elongation factor 2 kinase in rapid antidepressant action of ketamine[J]. Biol Psychiatry, 2013, 73(12): 1199-1203.
27	Gill JS, Jamwal S, Kumar P, et al. Sertraline and venlafaxine improves motor performance and neurobehavioral deficit in quinolinic acid induced Huntington's like symptoms in rats: possible neurotransmitters modulation[J]. Pharmacol Rep, 2017, 69(2): 306-313.
28	Haroon E, Chen XC, Li ZH, et al. Increased inflammation and brain glutamate define a subtype of depression with decreased regional homogeneity, impaired network integrity, and anhedonia[J]. Transl Psychiatry, 2018, 8(1): 189.
29	Beggiato S, Tanganelli S, Fuxe K, et al. Endogenous kynurenic acid regulates extracellular GABA levels in the rat prefrontal cortex[J]. Neuropharmacology, 2014, 82: 11-18.
30	Savitz J, Drevets WC, Smith CM, et al. Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder[J]. Neuropsychopharmacology, 2015, 40(2): 463-471.
31	Vichaya EG, Laumet G, Christian DL, et al. Motivational changes that develop in a mouse model of inflammation-induced depression are independent of indoleamine 2, 3 dioxygenase[J]. Neuropsychopharmacology, 2019, 44(2): 364-371.
32	Antoniades C, Cunnington C, Antonopoulos A, et al. Induction of vascular GTP-cyclohydrolase Ⅰ and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis[J]. Circulation, 2011, 124(17): 1860-1870.
33	Strasser B, Sperner-Unterweger B, Fuchs D, et al. Mechanisms of inflammation-associated depression: immune influences on tryptophan and phenylalanine metabolisms[J]. Curr Top Behav Neurosci, 2017, 31: 95-115.
34	Neurauter G, Schröcksnadel K, Scholl-Bürgi S, et al. Chronic immune stimulation correlates with reduced phenylalanine turnover[J]. Curr Drug Metab, 2008, 9(7): 622-627.
35	Capuron L, Schroecksnadel S, Féart C, et al. Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms[J]. Biol Psychiatry, 2011, 70(2): 175-182.
36	Felger JC, Li L, Marvar PJ, et al. Tyrosine metabolism during interferon-α administration: association with fatigue and CSF dopamine concentrations[J]. Brain Behav Immun, 2013, 31: 153-160.
37	Haruki H, Hovius R, Pedersen MG, et al. Tetrahydrobiopterin biosynthesis as a potential target of the kynurenine pathway metabolite xanthurenic acid[J]. J Biol Chem, 2016, 291(2): 652-657.
38	Sas K, Szabó E, Vécsei L. Mitochondria, oxidative stress and the kynurenine system, with a focus on ageing and neuroprotection[J]. Molecules, 2018, 23(1): E191.
39	Felger JC, Treadway MT. Inflammation effects on motivation and motor activity: role of dopamine[J]. Neuropsychopharmacology, 2017, 42(1): 216-241.

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