JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (2): 241-245.doi: 10.3969/j.issn.1674-8115.2021.02.018

• Review • Previous Articles     Next Articles

Research advances in inflammatory mechanism of anhedonia

Ze-nan WU(), Chen ZHANG()   

  1. Biochemical Pharmacology Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Received:2020-02-14 Online:2021-02-28 Published:2021-02-28
  • Contact: Chen ZHANG;
  • Supported by:
    National Key Research and Development Program of China(2018YFC1314302);National Natural Science Foundation of China(81471358);Western Medicine Guide Project of Science and Technology Commission of Shanghai Municipality(19411969300);Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20152530)


Anhedonia, a typical symptom of many mental diseases, is also an important indicator for treatment outcome. Further exploration of the mechanism of anhedonia and clear definition and illustration of its pathophysiological basis are helpful to the diagnosis and treatment of related diseases. In recent years, converging evidence has implicated that inflammation-driven alterations in kynurenine pathway (KP) and tetrahydrobiopterin (BH4) metabolism lead to nerve injury and disturbance of neurotransmitter in reward circuit, which is closely related to the emergence and development of anhedonia. Therefore, this review aims to summarize the research advances in the inflammatory mechanism of anhedonia, with the emphasis on both KP and BH4 metabolism.

Key words: anhedonia, reward circuit, inflammation, kynurenine pathway, tetrahydrobiopterin

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