›› 2018, Vol. 38 ›› Issue (8): 990-.doi: 10.3969/j.issn.1674-8115.2018.08.022

• Review • Previous Articles     Next Articles

Effect of imblanced vaginal flora on female infertility

CHU Wei-wei, XU Jie-ying, CHEN Zi-jiang, DU Yan-zhi   

  1. Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200135, China
  • Online:2018-08-28 Published:2018-09-11
  • Supported by:
    National Natural Science Foundation of China, 81671414; Shanghai Municipal Education Commission— Gaofeng Clinical Medicine Support, 20152510

Abstract: Recently the incidence of female infertility is on the rise. The variable and complicated caof infertility makes it difficult to diagnose in clinical practise. The relationship between vaginal flora and host immune system plays a vital role in female physiological function. Vaginal microbiota dysbiosis may be related to all kinds of infertility, such as tube infertility, endometriosis, anovulatory infertility and idiopathic infertility. In other words, vaginal microbiota dysbiosis may take part in the infertile process. For now the mechanism is far clear. Some scientists suppose that Lactobacillus deficiency, chronic inflamationandlow estrogen levelmight get involved inthispathophysiological progression,which needs to be studied in the furture.

Key words: vaginal microbiota, femaleinfertility, bacterialvaginosis, inflammation

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