Journal of Shanghai Jiao Tong University (Medical Science) >

2021 , Vol. 41 >Issue 8: 1125 - 1128

DOI: https://doi.org/10.3969/j.issn.1674-8115.2021.08.022

Brief original article

Effects of different continuous infusion rates of cisatracurium on muscle relaxation and recovery of muscle relaxation during upper abdominal laparotomy

  • Kai HE ,
  • Yan LUO ,
  • Chun-mei XU ,
  • Wei-fang JIN
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  • 1.Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    2.Department of Anesthesiology, Shanghai Civil Aviation Hospital/Gubei Branch of Ruijin Hospital, Shanghai 200336, China
JIN Wei-fang, E-mail: 630792802@qq.com.

Online published: 2021-08-13

Supported by

Scientific Research Project of Changning District Health and Family Planning Commission(20174Y019)

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Abstract

Objective

·To investigate the effects of different continuous infusion rates of cisatracurium on muscle relaxation and recovery of muscle relaxation in upper abdominal laparotomy.

Methods

·From January 2019 to January 2020, 60 patients scheduled for upper abdominal laparotomy in Shanghai Civil Aviation Hospital/Gubei Branch of Ruijin Hospital were randomly divided into low dosage [1.0 μg/(kg·min)] group (L group), middle dosage [1.5 μg/(kg·min)] group (M group) and high dosage [2.0 μg/(kg· min)] group (H group), according to the speed of intraoperative pump injection of cisatracurium, with 20 cases in each group. The amount of cisatracurium during the induction period, the cumulative pumping dosage during the operation, intraoperative muscle relaxation satisfaction, the time from drug withdrawal to the train of four stimulation (TOF) ratio recovery to 0.25, 0.75, 0.80 and 0.90 (TOFr 0.25, TOFr 0.75, TOFr 0.80, TOFr 0.90) and extubation time were recorded and compared among the three groups.

Results

·There was no significant difference in the dosage of cisatracurium during induction among the three groups (P=0.662). The cumulative pump the dosage in the L group was lower than those in the M and H groups (P=0.025). There was no significant difference in intraoperative muscle relaxation satisfaction among the three groups (P=1.000). TOFr 0.25, TOFr 0.75, TOFr 0.80, TOFr 0.90 and extubation time in the L group were significantly shorter than those in the M and H groups (P=0.000), but there was no significant difference between M group and H group (P>0.05).

Conclusion

·Continuous infusion of cisatracurium at the rate of 1.0 μg/(kg·min) during upper abdominal laparotomy can provide a good state of muscle relaxation. The increase of pump dosage can not significantly improve the effect of muscle relaxation, but can prolong the recovery time of muscle relaxation and extubation time.

Key words： cisatracurium; continuous pumping rate; upper abdominal laparotomy; muscle relaxation; muscle relaxation recovery

Cite this article

Kai HE , Yan LUO , Chun-mei XU , Wei-fang JIN . Effects of different continuous infusion rates of cisatracurium on muscle relaxation and recovery of muscle relaxation during upper abdominal laparotomy[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2021 , 41(8) : 1125 -1128 . DOI: 10.3969/j.issn.1674-8115.2021.08.022

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