Journal of Shanghai Jiao Tong University (Medical Science) >

2022 , Vol. 42 >Issue 2: 197 - 204

DOI: https://doi.org/10.3969/j.issn.1674-8115.2022.02.010

Evidence-based medicine

Association between interleukin-1B-511C/T gene polymorphism and coronary atherosclerotic heart disease: a meta-analysis

  • Yingchao TAN ,
  • Junyue YANG ,
  • Lina WANG
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  • Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, China
WANG Lina, E-mail: lnwang@seu.edu.cn.

Received date: 2021-09-22

  Online published: 2022-03-17

Supported by

National Natural Science Foundation of China(81673259);Natural Science Foundation of Jiangsu Province(BK20161435);Postgraduate Research＆Practice Innovation Program of Jiangsu Province(SJCX20_0062);Fundamental Research Funds for the Central Universities of China(3225002108D)

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Abstract

Objective

·To evaluate the association between interleukin-1B (IL-1B)-511C/T gene polymorphism and the risk of coronary atherosclerotic heart disease (CHD).

Methods

·Published case-control studies on IL-1B-511C/T gene polymorphism and CHD in PubMed, Web of Science, Scopus and Embase databases were retrieved from the establishment of each database to June 2021. Two researchers independently conducted literature screening and data extraction. The extracted data included the name of the first author, the year of publication, the race of the research objects, matching factors, the source of the control group, genotyping method, sample size, genotype frequency, allele frequency, and whether to meet Hardy-Weinberg equilibrium. Meta-analysis was performed by using Stata 16.0 software.

Results

·A total of 9 literatures were included, including 2 190 patients with CHD and 2 385 controls. Meta-analysis showed that there was no significant correlation between IL-1B -511C/T gene polymorphism and the risk of CHD (T vs C: OR =1.21, 95% CI 0.91?1.61; TT+CT vs CC: OR=1.24, 95% CI 0.88?1.75; CC+CT vs TT: OR=1.28, 95% CI 0.86?1.90). Subgroup analysis showed that compared with individuals with C allele and CC genotype in the Chinese population, the individuals with T allele and TT+CT genotype had a 85% and 116% increased risk of CHD, respectively (T vs C: OR=1.85, 95% CI 1.02?3.36; TT+CT vs CC: OR=2.16, 95% CI 1.10?4.24). In hospital-based case-control studies, compared with individuals with CC+CT genotype, the individuals with TT genotype had a 59% increased risk of CHD (OR=1.59, 95% CI 1.03?2.47).

Conclusion

·There is no significant association between IL-1B-511C/T gene polymorphism and the risk of CHD. In the Chinese population, individuals with T allele and TT+TC genotype have a higher risk of CHD.

Key words： interleukin-1; gene polymorphism; -511C/T; coronary atherosclerotic heart disease (CHD); meta-analysis

Cite this article

Yingchao TAN , Junyue YANG , Lina WANG . Association between interleukin-1B-511C/T gene polymorphism and coronary atherosclerotic heart disease: a meta-analysis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022 , 42(2) : 197 -204 . DOI: 10.3969/j.issn.1674-8115.2022.02.010

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