Journal of Shanghai Jiao Tong University (Medical Science) >
Role of SUMOylation in spermatogenesis
Received date: 2022-02-11
Accepted date: 2022-07-01
Online published: 2022-09-04
Supported by
Medical Innovation Research Project of Shanghai Scientific and Technological Project(20Y11907600);National Natural Science Foundation of China(82171586)
SUMOylation is a reversible post-translational modification of proteins, which is involved in many important biological processes, such as transcriptional regulation, signal transduction, and DNA damage repair. It is found that the overall expressions and localizations of SUMOylation change dynamically in spermatogenesis, suggesting that it may be involved in key events in the process. Spermatogenesis is a series of processes regulated by complex biological crosstalk. In the seminiferous tubules, spermatogenic cells undergo three stages, that is, the proliferation and differentiation of spermatogonial stem cells, the meiosis of spermatocytes and spermiogenesis, and eventually form highly specialized spermatozoa. In this process, the effects and mechanisms of SUMOylation in spermatogenesis have not been clear. Therefore, this review summarizes the effect of the SUMOylation enzyme system, SUMO family and SUMO-specific proteases family in spermatogenesis.
Key words： spermatogenesis; SUMOylation; post-translational modification
Jiayan LUAN , Peng LI , Bangmin HAN . Role of SUMOylation in spermatogenesis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022 , 42(7) : 925 -930 . DOI: 10.3969/j.issn.1674-8115.2022.07.012
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