Journal of Shanghai Jiao Tong University (Medical Science) >

2023 , Vol. 43 >Issue 2: 208 - 214

DOI: https://doi.org/10.3969/j.issn.1674-8115.2023.02.010

Evidence-based medicine

Effectiveness of vitamin E on oral mucositis caused by radiotherapy and chemotherapy: a meta-analysis

  • Yanjing LIANG ,
  • Chuxian HUANG ,
  • Hongyan LI ,
  • Lili HOU
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  • 1.School of Nursing, Shanghai Jiao Tong University, Shanghai 200025, China
    2.Nursing Department, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
    3.Nursing Department, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China
HOU Lili, E-mail：pisces_liz@163.com.

Received date: 2022-05-20

  Accepted date: 2022-11-30

  Online published: 2023-02-28

Supported by

Innovation Research Team of High-level Local Universities in Shanghai(SHSMU-ZDCX20212802)

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Abstract

Objective ·To examine, using a systematic review and meta-analysis, the effectiveness of vitamin E on treating oral mucositis caused by radiotherapy and chemotherapy. Methods ·A systematic literature search was performed by using PubMed, Embase, Cochrane Library, Web of Science, CINAHL, OpenGrey, Chinese biomedical literature database (CBM), Chinese national knowledge infrastructure (CNKI), Wanfang Data, and China Science and Technology Journal Database (VIP). The retrieval time was up to March 2022. The risk of bias was assessed by using the Cochrane Risk-of-Bias tool, version 2.0. RevMan 5.4 was used for meta-analysis. Results ·A total of 563 literatures were retrieved. A total of 7 randomized controlled trials were included. The results of meta-analysis revealed that vitamin E supplementation did not significantly affect oral mucositis caused by chemoradiotherapy (RR=0.44, 95%CI 0.15?1.25, Z=1.54, P=0.120). However, vitamin E may have some effect on severe oral mucositis (RR=0.22, 95%CI 0.11?0.43, Z=4.33, P=0.000). Conclusion ·It cannot be explained that vitamin E can effectively treat oral mucositis caused by radiotherapy and chemotherapy, but vitamin E may be effective for severe oral mucositis.

Key words： vitamin E; oral mucositis; randomized controlled trial; meta analysis

Cite this article

Yanjing LIANG , Chuxian HUANG , Hongyan LI , Lili HOU . Effectiveness of vitamin E on oral mucositis caused by radiotherapy and chemotherapy: a meta-analysis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023 , 43(2) : 208 -214 . DOI: 10.3969/j.issn.1674-8115.2023.02.010

References

1 周琳琳, 苏少晨, 翟田田, 等. 蜂蜜预防放化疗导致的口腔黏膜炎及相关疼痛的系统评价[J]. 中国护理管理, 2019, 19(5): 693-700.
1 ZHOU L L, SU S C, ZHAI T T, et al. Prophylactic effects of honey use on radio or chemotherapy-induced oral mucositis and associated pain: a systematic review[J]. Chinese Nursing Management, 2019, 19(5): 693-700.
2 VILLA A, SONIS S T. Mucositis: pathobiology and management[J]. Curr Opin Oncol, 2015, 27(3): 159-164.
3 AGARWAL P, UPADHYAY R, AGARWAL A. Radiotherapy complications and their possible management in the head and neck region[J]. Indian J Dent Res, 2012, 23(6): 843.
4 KUO C C, WANG R H, WANG H H, et al. Meta-analysis of randomized controlled trials of the efficacy of propolis mouthwash in cancer therapy-induced oral mucositis[J]. Support Care Cancer, 2018, 26(12): 4001-4009.
5 TREISTER N, NIEDER M, BAGGOTT C, et al. Caphosol for prevention of oral mucositis in pediatric myeloablative haematopoietic cell transplantation[J]. Br J Cancer, 2017, 116(1): 21-27.
6 周怡韵, 杨永宾, 蔡美琴. 维生素E及其对癌症作用的新进展[J]. 中国临床营养杂志, 2007, 15(5): 326-331.
6 ZHOU Y Y, YANG Y B, CAI M Q. Advances in Vitamin E and its potential role in cancer[J]. Chinese Journal of Clinical Nutrition, 2007, 15(5): 326-331.
7 WADLEIGH R G, REDMAN R S, GRAHAM M L, et al. Vitamin E in the treatment of chemotherapy-induced mucositis[J]. Am J Med, 1992, 92(5): 481-484.
8 GHOREISHI Z, SHIDFAR F, IRAVANI M, et al. Effect of vitamin E on chemotherapy-induced mucositis and neutropenia in leukemic patients undergoing bone marrow transplantation[J]. Asia Pac J Clin Oncol, 2007, 3(3): 113-118.
9 LOPEZ I, GOUDOU C, RIBRAG V, et al. Treatment of mucositis with vitamin E during administration of neutropenic antineoplastic agents[J]. Ann Med Interne (Paris), 1994, 145(6): 405-408.
10 PALMER M K. WHO handbook for reporting results of cancer treatment[J]. Br J Cancer, 1982, 45(3): 484-485.
11 TROTTI A, COLEVAS A D, SETSER A, et al. CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment[J]. Semin Radiat Oncol, 2003, 13(3): 176-181.
12 COX J D, STETZ J, PAJAK T F. Toxicity criteria of the radiation therapy oncology group (RTOG) and the European organization for research and treatment of cancer (EORTC)[J]. Int J Radiat Oncol Biol Phys, 1995, 31(5): 1341-1346.
13 HIGGINS J P, GREEN S. Cochrane handbook for systematic reviews of interventions[M]. 2nd ed. Chichester: John Wiley & Sons, 2019: 177-227.
14 SAYED R, EL WAKEEL L, SAAD A S, et al. Pentoxifylline and vitamin E reduce the severity of radiotherapy-induced oral mucositis and dysphagia in head and neck cancer patients: a randomized, controlled study[J]. Med Oncol, 2019, 37(1): 8.
15 KHURANA H, PANDEY R K, SAKSENA A K, et al. An evaluation of vitamin E and pycnogenol in children suffering from oral mucositis during cancer chemotherapy[J]. Oral Dis, 2013, 19(5): 456-464.
16 李小芳, 公霞, 朱庆芬, 等. 维生素加金因肽防治鼻咽癌放射性口腔炎的临床观察[J]. 国际护理学杂志, 2007, 26(5): 528-530.
16 LI X F, GONG X, ZHU Q F, et al. Clinical observation of vitamin plus goldin peptide for the prevention and treatment of radiation stomatitis in nasopharyngeal carcinoma[J]. International Journal of Nursing, 2007, 26(5): 528-530.
17 林桂兰. 维生素E外涂治疗口腔溃疡[J]. 护理研究, 2005, 19(9): 823.
17 LIN G L. Vitamin E external applying to treat patients with dental ulcer[J]. Chinese Nursing Research, 2005, 19(9): 823.
18 FERREIRA P R, FLECK J F, DIEHL A, et al. Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: a double-blind randomized trial[J]. Head Neck, 2004, 26(4): 313-321.
19 朱晓燕, 高明, 林金娥. 维生素E局部涂用治疗化疗后口腔溃疡[J]. 中华护理杂志, 1994, 29(10): 612.
19 ZHU X Y, GAO M, LIN J E. Topical application of vitamin E for post-chemotherapy mouth ulcers[J]. Chinese Journal of Nursing, 1994, 29(10): 612.
20 LYONS A J, BRENNAN P A. Pentoxifylline: a review of its use in osteoradionecrosis[J]. Br J Oral Maxillofac Surg, 2017, 55(3): 230-234.
21 MISIRLIOGLU C H, DEMIRKASIMOGLU T, KUCUKPLAKCI B, et al. Pentoxifylline and alpha-tocopherol in prevention of radiation-induced lung toxicity in patients with lung cancer[J]. Med Oncol, 2007, 24(3): 308-311.
22 STARASOLER S, HABER G S. Use of vitamin E oil in primary herpes gingivostomatitis in an adult[J]. N Y State Dent J, 1978, 44(9): 382-383.
23 ALT?NER A, ATALAY H, B?LAL T. Vitamin E as an antioxidant[J]. Bal?kes?r Heal Sci J, 2017, 6(3): 149-157.
24 BOWEN J, AL-DASOOQI N, BOSSI P, et al. The pathogenesis of mucositis: updated perspectives and emerging targets[J]. Support Care Cancer, 2019, 27(10): 4023-4033.
25 BLOCK K I, KOCH A C, MEAD M N, et al. Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials[J]. Int J Cancer, 2008, 123(6): 1227-1239.
26 代英波. 口服维生素E防治化疗后口腔粘膜溃疡[J]. 牡丹江医学院学报, 2008(3): 103-104.
26 DAI Y B. Oral vitamin E for prevention and treatment of oral mucosal ulcers after chemotherapy[J]. Journal of Mudanjiang Medical University, 2008(3): 103-104.
27 CHAITANYA N C, MUTHUKRISHNAN A, BABU D B G, et al. Role of vitamin E and vitamin A in oral mucositis induced by cancer chemo/radiotherapy: a meta-analysis[J]. J Clin Diagn Res, 2017, 11(5): ZE06-ZE09.
28 HE M X, ZHANG B H, SHEN N P, et al. A systematic review and meta-analysis of the effect of low-level laser therapy (LLLT) on chemotherapy-induced oral mucositis in pediatric and young patients[J]. Eur J Pediatr, 2018, 177(1): 7-17.
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