Journal of Shanghai Jiao Tong University (Medical Science) >

2023 , Vol. 43 >Issue 9: 1153 - 1161

DOI: https://doi.org/10.3969/j.issn.1674-8115.2023.09.009

Clinical research

Effect of somatic symptoms, anxiety and depression on clinical prognosis in patients with chronic heart failure

  • Qifan LU ,
  • Qiming LIU ,
  • Hongmei ZHOU ,
  • Yezi CHAI ,
  • Meng JIANG ,
  • Jun PU
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  • Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
PU Jun, E-mail: pujun310@hotmail.com.
JIANG Meng, E-mail: jiangmeng0919@163.com

Received date: 2023-03-27

  Accepted date: 2023-05-24

  Online published: 2023-09-28

Supported by

National Natural Science Foundation of China(81971570);China International Medical Foundation(Z-2019-42-1908-2);Three-year Clinical Research Plan of Shanghai Hospital Development Center(SHDC2020CR2025B);Advanced Technology Leader of Shanghai Science and Technology Committee(21XD143210);Innovation Research Project of Shanghai Science and Technology Commission(20Y11910500);Shanghai Pudong New Area Health Commission Joint Research Project(PW2018D-03);Medical-Engineering Cross Research of Shanghai Jiao Tong University(YG2019ZDA13);“Two-hundred Talents” Program of Shanghai Jiao Tong University School of Medicine(20172014)

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Abstract

Objective ·To explore the association of somatizatic symptoms, anxiety and depression with clinical prognosis in the patients with chronic heart failure (CHF). Methods ·The patients with CHF who visited the Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine from January 2018 to December 2021 were included. Demographic data and clinical features of the patients were collected. The Self-reported Somatic Symptom Scale of China (SSS-CN), the Patient Health Questionnaire-9 (PHQ-9), and the Generalized Anxiety Disorder-7 (GAD-7) were used to evaluate the patients′ conditions. Telephone follow-up was conducted at the 12th month after the first visit, and the specific information of the patients′ end-point events (including death, re-hospitalization, causes of death and re-hospitalization) was collected. Survival curve and Cox regression analysis were used to evaluate the clinical prognosis of the patients. Results ·A total of 195 patients were included. The SSS-CN scores in CHF patients were different between the two genders, among the different heart rate groups and the different cardiac function grades of New York Heart Association (NYHA), also between the patients with anxiety/depression or not (all P<0.05). Survival curve analysis showed that overall survival rate of patients in the moderate-severe somatic symptoms group was lower than that of the patients in the normal-mild group (Log rank P=0.020). Cox regression analysis showed that compared with the normal-mild group, the patients in the moderate-severe somatic symptoms group had a higher risk of all-cause death [hazard ratio (HR)=2.797, 95%CI 1.135－6.890]; the CHF patients with depressive symptoms had a higher risk of all-cause death (HR=2.883, 95%CI 1.150－6.984). Compared with the normal-mild group, the patients with moderate-severe somatic symptoms had a higher risk of cardiovascular death (HR=2.784, 95%CI 1.073－7.226). The CHF patients with depressive symptoms had a higher risk of cardiovascular death (HR=2.823, 95%CI 1.087－7.330). There were no statistically differences in anxiety, depression, somatization symptoms and their severity between all-cause hospitalization and hospitalization due to CHF. Conclusion ·The moderate-severe somatic symptoms and depression are the risk factors of all-cause death and cardiovascular death in the patients with CHF.

Key words： chronic heart failure; somatic symptom; depression; anxiety

Cite this article

Qifan LU , Qiming LIU , Hongmei ZHOU , Yezi CHAI , Meng JIANG , Jun PU . Effect of somatic symptoms, anxiety and depression on clinical prognosis in patients with chronic heart failure[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023 , 43(9) : 1153 -1161 . DOI: 10.3969/j.issn.1674-8115.2023.09.009

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