Journal of Shanghai Jiao Tong University (Medical Science) >

2025 , Vol. 45 >Issue 1: 107 - 112

DOI: https://doi.org/10.3969/j.issn.1674-8115.2025.01.013

Review

Research progress on the neuroinflammation mechanisms in bipolar disorder

  • WANG Xiaohong ,
  • FANG Yiru
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  • 1.Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
    2.Department of Psychiatry & Affective Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
FANG Yiru, E-mail: yirufang@aliyun.com。

Received date: 2024-06-06

  Accepted date: 2024-11-25

  Online published: 2025-01-28

Supported by

Key Project of the Clinical Research Center, Shanghai Mental Health Center(CRC2021DX01)

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Abstract

Bipolar disorder (BD) is a chronic, recurrent mental illness characterized by extreme fluctuations in mood and state, clinically manifested as recurrent or alternating manic, depressive, and mixed episodes. The pathogenesis is complex and remains unknown, with neuroinflammation considered as a key factor in its development. In-depth research not only helps to understand the etiology, but also provides direction for the development of new therapeutic targets. This paper reviews recent studies on neuroinflammation in BD, discusses changes in peripheral and central inflammation and associated biomarkers, explores the underlying mechanisms of pathogenesis, and briefly describes the mechanisms and potential of mood stabilizers and new therapeutic drugs in anti-inflammatory effect, aiming to suggest possible future research directions.

Key words： bipolar disorder; neuroglial cell; neuroinflammation; biomarker

Cite this article

WANG Xiaohong , FANG Yiru . Research progress on the neuroinflammation mechanisms in bipolar disorder[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025 , 45(1) : 107 -112 . DOI: 10.3969/j.issn.1674-8115.2025.01.013

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