Journal of Shanghai Jiao Tong University (Medical Science) >

2025 , Vol. 45 >Issue 10: 1383 - 1389

DOI: https://doi.org/10.3969/j.issn.1674-8115.2025.10.014

Review

Research progress on ferroptosis of placental cells in recurrent spontaneous abortion

  • LI Guanghui ,
  • FENG Xiaoling
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  • 1.Graduate School, Heilongjiang University of Chinese Medicine, Harbin 150040, China
    2.Gynecology Department II, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, China
FENG Xiaoling, E-mail: doctorfengmen@163.com.

Received date: 2025-05-05

  Accepted date: 2025-09-19

  Online published: 2025-10-20

Supported by

National Natural Science Foundation of China(82174421,82205163);Natural Science Foundation of Heilongjiang Province(SC2022ZX06C0002);Chinese Medicine Evidence-Based Capacity Enhancement Program (Letter No. [2023] 24 of the State Science and Technology of Traditional Chinese Medicine)

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Abstract

Recurrent spontaneous abortion (RSA) is a pregnancy complication with a complex etiology that seriously threatens the fertility and physical and mental health of women of childbearing age. As the main component of the maternal-fetal interface, the placenta plays a central role in maternal and fetal health during pregnancy, and its dysfunction is closely associated with the development of RSA. Iron homeostasis is essential for supporting maternal needs, placental function, and fetal development. In recent years, ferroptosis, a novel form of cell death triggered by iron overload and the accumulation of lipid peroxides, has garnered increasing attention regarding its regulatory mechanisms in the physiological and pathological processes of the female reproductive system. Ferroptosis has been confirmed to correlate with placental pathology and to influence the pathogenesis of RSA. The placenta plays a crucial role in regulating iron transport. This paper systematically reviewed the mechanisms of ferroptosis in placental cells and its involvement in the pathogenesis of RSA by affecting trophoblast cell function, causing decidualization disorders, inducing angiogenesis defects, and the potential of ferroptosis-related molecules in the treatment of RSA was analyzed, with the aim of providing research directions for improving the pregnancy outcomes in patients with RSA.

Key words： recurrent spontaneous abortion; placenta; ferroptosis; trophoblast cell; decidualization; angiogenesis

Cite this article

LI Guanghui , FENG Xiaoling . Research progress on ferroptosis of placental cells in recurrent spontaneous abortion[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025 , 45(10) : 1383 -1389 . DOI: 10.3969/j.issn.1674-8115.2025.10.014

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