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Research progress of trans-differentiation of hepatic oval cells into pancreatic beta cells

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  • Department of Endocrinology and Metabolism, The Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China

Online published: 2011-02-01

Abstract

Hepatic oval cells are pluripotent stem cells, which can be induced to trans-differentiate into pancreatic β cells under certain conditions. Many factors such as diabetes mellitus, extracellular matrix, cytokines and pancreatic islet transcription factor may be involved in the trans-differentiation of hepatic oval cells into pancreatic β cells. This article reviews the influential factors in the trans-differentiation of hepatic oval cells into pancreatic β cells.

Cite this article

LI Ying, LU Ying-li . Research progress of trans-differentiation of hepatic oval cells into pancreatic beta cells[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2011 , 31(1) : 104 . DOI: 10.3969/j.issn.1674-8115.2011.01.024

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