›› 2011, Vol. 31 ›› Issue (1): 104-.doi: 10.3969/j.issn.1674-8115.2011.01.024

• Review • Previous Articles     Next Articles

Research progress of trans-differentiation of hepatic oval cells into pancreatic beta cells

LI Ying, LU Ying-li   

  1. Department of Endocrinology and Metabolism, The Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China
  • Online:2011-01-28 Published:2011-02-01

Abstract:

Hepatic oval cells are pluripotent stem cells, which can be induced to trans-differentiate into pancreatic β cells under certain conditions. Many factors such as diabetes mellitus, extracellular matrix, cytokines and pancreatic islet transcription factor may be involved in the trans-differentiation of hepatic oval cells into pancreatic β cells. This article reviews the influential factors in the trans-differentiation of hepatic oval cells into pancreatic β cells.

Key words: hepatic oval cells, pancreatic &beta, cell, diabetes mellitus, trans-differentiation, influential factor