Abstract:

Aquaporin-1 (AQP1), which has a special molecular structure and is regulated by many factors, is the earliest found and most widely distributed aquaporin (AQP). In addition to transporting water, AQP1 may participate in a variety of gas transportation and be involved in cell metastasis process. In heart tissues, AQP1 is mainly expressed in erythrocytes, capillary endothelial cells and myocardial cells. AQP1 is located in cytoplasma membrane of myocardial cells, and may participate in the process of excitation-contraction coupling and transportation of water, which regulates water metabolism in various physiological and pathological process. Cardiac surgery with extracorporeal circulation can influence the expression and activity of AQPs, leading to cardiac edema. The investigations of AQPs have important guiding effects in clinical practice.

Key words: aquaporin, myocardial edema, regulation, cardiopulmonary bypass