›› 2011, Vol. 31 ›› Issue (1): 99-.doi: 10.3969/j.issn.1674-8115.2011.01.023

• Review • Previous Articles     Next Articles

Research progress of aquaporin-1 and its role in heart

YAN Yu-mei1, MEI Ju2, SUN Kun1, DING Fang-bao2   

  1. 1.Department of Cardiology, Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China;2.Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2011-01-28 Published:2011-02-01
  • Supported by:

    National Natural Science Foundation of China, 30872558


Aquaporin-1 (AQP1), which has a special molecular structure and is regulated by many factors, is the earliest found and most widely distributed aquaporin (AQP). In addition to transporting water, AQP1 may participate in a variety of gas transportation and be involved in cell metastasis process. In heart tissues, AQP1 is mainly expressed in erythrocytes, capillary endothelial cells and myocardial cells. AQP1 is located in cytoplasma membrane of myocardial cells, and may participate in the process of excitation-contraction coupling and transportation of water, which regulates water metabolism in various physiological and pathological process. Cardiac surgery with extracorporeal circulation can influence the expression and activity of AQPs, leading to cardiac edema. The investigations of AQPs have important guiding effects in clinical practice.

Key words: aquaporin, myocardial edema, regulation, cardiopulmonary bypass