›› 2011, Vol. 31 ›› Issue (1): 95-.doi: 10.3969/j.issn.1674-8115.2011.01.022

• Review • Previous Articles     Next Articles

Research progress of promoter methylation of DNA repair related genes and tumor chemoresistance

HAN Jing, LI Jiang   

  1. Department of Oral Pathology, The Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
  • Online:2011-01-28 Published:2011-02-01
  • Supported by:

    National Natural Science Foundation of China, 30872905, 81072211；Shanghai Key Discipline Construction Project, S30206；Shanghai Science and Technology Committee Foundation, 08DZ2271100

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2030

Abstract:

The DNA repair ability of tumor cells is closely correlated with tumor chemosensitivity.  Promoter methylation of DNA may lead to transcriptional inactivation, gene silence and alteration of protein expression of DNA repair related genes, which in turn influences the ability of DNA repair, and therefore leads to the intrinsic and acquired tumor chemoresistance. This article briefly summaries the relationship between tumor chemoresistance and promoter methylation of DNA repair related genes such as O6-Methylguanine-DNA methyltransferase (MGMT), human mutL homologue 1 (hMLH1) and Fanconi anemia complementation group F (FANCF).

Key words: promoter methylation, DNA repair, chemoresistance, alkylating agents, O6-methylguanine-DNA methyltransferase, Fanconi anemia complementation group F