›› 2011, Vol. 31 ›› Issue (1): 89-.doi: 10.3969/j.issn.1674-8115.2011.01.021

• Review • Previous Articles     Next Articles

Research progress of gene polymorphisms and chemosensitivity for gastric cancer

ZHENG Lei-zhen1, WANG Zhi-jie2   

  1. 1.Department of Oncology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China;2.Department of Oncology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
  • Online:2011-01-28 Published:2011-02-01
  • Supported by:

    Shanghai Municipal Health Bureau Foundation, 2008135


Chemotherapy plays an important role in the treatment of gastric cancer, with fluorouracil and platinum being the common drugs. However, patients respond differently to the same drugs, the mechanism of which may be important to be clarified to improve the efficacy of chemotherapy. This review systematically highlights the relationship between gene polymorphisms and chemosensitivity for gastric cancer according to the latest studies, which may provide evidences for the personalised treatment for gastric cancer.

Key words: gastric cancer, chemosensitivity, polymorphisms