›› 2018, Vol. 38 ›› Issue (7): 835-.doi: 10.3969/j.issn.1674-8115.2018.07.023

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Roles of TRIM28 in tumorigenesis and embryogenesis

LIU Ye, WANG Yin-yu, XU Jing-jing, HUANG He-feng   

  1. 1. Institute of Embryo-Fetal Original Adult Disease, The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. The Key Laboratory of Reproductive Genetics (Ministry of Education), Zhejiang University School of Medicine, Hangzhou 310058, China
  • Online:2018-07-28 Published:2018-07-30
  • Supported by:
    Doctoral Innovation Fund of Shanghai Jiao Tong University School of Medicine, BXJ201640

Abstract: TRIM28, known as a kind of macro-molecules, consists of multiple domains and belongs to one of human tripartite motif-containing proteins families. This superfamily contains more than 60 proteins in total and is characterizedfour conservative domains, also referred to the RBCC domain, which is a RING (really interesting new gene) finger, two B-boxes (type 1 and type 2) and a leucine zipper coiled-coil region. TRIM28 plays its pivotal roles in transcriptional co-activation or co-repressioninteracting directly with transcription factors, within which is a Kruppel-associated box domain (KRAB domain). Moreover, itis critical during the development of embryos, thedifferentiation of cells and the regulation of cancers.

Key words: transcriptional regulation, co-activator, co-repressor, cancer, epigenetics, methylation

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