Abstract: TRIM28, known as a kind of macro-molecules, consists of multiple domains and belongs to one of human tripartite motif-containing proteins families. This superfamily contains more than 60 proteins in total and is characterizedfour conservative domains, also referred to the RBCC domain, which is a RING (really interesting new gene) finger, two B-boxes (type 1 and type 2) and a leucine zipper coiled-coil region. TRIM28 plays its pivotal roles in transcriptional co-activation or co-repressioninteracting directly with transcription factors, within which is a Kruppel-associated box domain (KRAB domain). Moreover, itis critical during the development of embryos, thedifferentiation of cells and the regulation of cancers.

Key words: transcriptional regulation, co-activator, co-repressor, cancer, epigenetics, methylation