Function of human nucleic acid alkylation damage repair enzyme ALKBH3 in cancer progression and oncotherapy

doi:10.3969/j.issn.1674-8115.2021.05.021

Abstract

Abstract:

Human nucleic acid alkylation damage repair enzyme ALKBH3 (alpha-ketoglutarate-dependent dioxygenase homolog 3) belongs to Fe²⁺/α-Ketoglutarate (α-KG)-dependent AlkB dioxygenase family, and shares a highly conserved catalytic domain through the entire family. ALKBH3 specifically recognizes N¹-methyl adenine and N³-methyl cytosine on single-stranded DNA or RNA, and catalyzes their methyl group removal for alkylation damage repair. Previous studies have shown that ALKBH3 is highly expressed in various solid tumors, and thereby it has been considered as a potential anti-tumor drug target. Research of the structural function and regulation mechanism of ALKBH3 will help further understand the molecular mechanism in the DNA alkylation damage repair, and lay the foundation for the development of anti-tumor drugs targeting ALKBH3.

Key words: alpha-ketoglutarate-dependent dioxygenase homolog 3, ALKBH3, DNA alkylation damage repair, cancer

CLC Number:

Jing-yan HU, Lin ZHANG, Liang ZHANG. Function of human nucleic acid alkylation damage repair enzyme ALKBH3 in cancer progression and oncotherapy[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(5): 684-689.

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References 46

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