JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (5): 684-689.doi: 10.3969/j.issn.1674-8115.2021.05.021

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Function of human nucleic acid alkylation damage repair enzyme ALKBH3 in cancer progression and oncotherapy

Jing-yan HU(), Lin ZHANG, Liang ZHANG()   

  1. Department of Pharmacology, Shanghai Jiao Tong University College of Basic Medical Science, Shanghai 200025, China
  • Online:2021-05-28 Published:2021-05-27
  • Contact: Liang ZHANG;
  • Supported by:
    National Natural Science Foundation of China(21722802);Innovative Research Team of High-Level Local Universities in Shanghai(SSMU-ZLCX20180702)


Human nucleic acid alkylation damage repair enzyme ALKBH3 (alpha-ketoglutarate-dependent dioxygenase homolog 3) belongs to Fe2+/α-Ketoglutarate (α-KG)-dependent AlkB dioxygenase family, and shares a highly conserved catalytic domain through the entire family. ALKBH3 specifically recognizes N1-methyl adenine and N3-methyl cytosine on single-stranded DNA or RNA, and catalyzes their methyl group removal for alkylation damage repair. Previous studies have shown that ALKBH3 is highly expressed in various solid tumors, and thereby it has been considered as a potential anti-tumor drug target. Research of the structural function and regulation mechanism of ALKBH3 will help further understand the molecular mechanism in the DNA alkylation damage repair, and lay the foundation for the development of anti-tumor drugs targeting ALKBH3.

Key words: alpha-ketoglutarate-dependent dioxygenase homolog 3, ALKBH3, DNA alkylation damage repair, cancer

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