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Research advances in transcription regulation related to azole resistance of Candida albicans

LIU Jin-yan1, SHI Ce2, WANG Ying2, LI Wen-jing2, ZHAO Yue2, ZHU Wei-wei1, XIANG Ming-jie1,2   

  1. 1.Department of Clinical Laboratory, Luwan Branch, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China; 2.Department of Clinical Laboratory; Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2016-02-28 Published:2016-03-29
  • Supported by:

    Project of Shanghai Key Specialty, ZK2012A21; Foundation of Shanghai Municipal Science and Technology Commission, 15ZR1426900; Foundation of Shanghai Municipal Huangpu District Health Bureau, 2012-HGG-44; Shanghai Municipal Huangpu District Health System Program for Youths, RCPY1407

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Abstract:

In recent 30 years, Candida albicans has become the most common opportunistic pathogen that causes the incidence and mortality of patients with low immunity. With the frequent use of azole antifungal drugs, azole-resistant strains are often detected. Studies on the mechanism of drug resistance have drawn more and more attention. In recent years, studies on the mechanism of transcriptional regulation have also made great progress. The cis-acting elements and trans-acting factors of the resistant-related encoding gene were identified and the acting mechanism was partially elucidated. In this paper, research advances in the transcription regulation related to azole resistance of Candida albicans are reviewed.

Key words: Candida albicans, transcriptional regulation, efflux pump, target enzyme, cis-acting regulatory elements, trans-acting factors