Research progress of penicillin-binding proteins and Gram-negative bacterial resistance
Online published: 2012-07-02
It has been identified that the modification of penicillin-binding proteins (PBPs) and the reduction of affinity for β-lactams are important mechanisms by which Gram-positive cocci acquire antibiotic resistance. However, among Gram-negative bacteria,the resistance caused by the modification of PBPs has been considered unusual, which neglects the role of PBPs in β-lactams resistance in Gram-negative bacteria.In this paper, the structure, function and research method of PBPs, and the relationship between PBPs and Gram-negative bacterial resistance are reviewed.
Key words: penicillin-binding proteins; Gram-negative bacteria; resistance
WANG Xin-hui, JIANG Yan-qun . Research progress of penicillin-binding proteins and Gram-negative bacterial resistance[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2012 , 32(6) : 820 . DOI: 10.3969/j.issn.1674-8115.2012.06.028
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