Review

Research progress of penicillin-binding proteins and Gram-negative bacterial resistance

Expand
  • Department of Clinical Laboratory, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China

Online published: 2012-07-02

Abstract

It has been identified that the modification of penicillin-binding proteins (PBPs) and the reduction of affinity for β-lactams are important mechanisms by which Gram-positive cocci acquire antibiotic resistance. However, among Gram-negative bacteria,the resistance caused by the modification of PBPs has been considered unusual, which neglects the role of PBPs in β-lactams resistance in Gram-negative bacteria.In this paper, the structure, function and research method of PBPs, and the relationship between PBPs and Gram-negative bacterial resistance are reviewed.

Cite this article

WANG Xin-hui, JIANG Yan-qun . Research progress of penicillin-binding proteins and Gram-negative bacterial resistance[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2012 , 32(6) : 820 . DOI: 10.3969/j.issn.1674-8115.2012.06.028

Outlines

/