The peripherally inserted central catheter (PICC) ruptured and the catheter tips migrated into cardiac chamber and pulmonary artery in one patient. For removal of the PICC, bilateral femoral vein puncture was performed, one 5F-PIG catheter and one guided wire were placed via femoral vein, one PICC tip was dragged into the inferior vena cava and was removed through vascular sheath with gooseneck snare. The PICC was removed successfully, with no infection and hemorrhage of puncture point after treatment.