Objective To explore the optimization design of bioinspired functionally graded interface layer of all ceramic restoration. Methods Three dimensional planar finite element model of bilayered ceramic/bioinspired functionally graded layer/cement/dentine was established. Experiment groupⅠ (Zirconia as the core material) and experiment group Ⅱ(Diene acid aluminum as the core material) were divided according to different core materials, and three dimensional finite element analysis was performed. The optimization analysis of graded change of elastic modulus of bioinspired functionally graded layer was conducted by first order optimization method. Besides, the three dimensional planar finite element model of bilayered ceramic/cement/dentine was served as control. Results For experiment groupⅠ, the stress uniformly distributed in bioinspired functionally graded layer with the maximum principal stress value of 23.0186 MPa, and a smooth stress transition from bioinspired functionally graded layer to cement was found. As for control group of experiment groupⅠ, stress concentration was found at the sub-surface of the core with the maximum principal stress value of 100.25 MPa. For experiment group Ⅱ, the stress uniformly distributed in bioinspired functionally graded layer with the maximum principal stress value of 15.9 665 MPa, and a smooth stress transition from bioinspired functionally graded layer to cement was found. As for control group of experiment group Ⅱ, stress concentration was found at the sub-surface of the core with the maximum principal stress value of 73.884 MPa. The optimization curves of elastic modulus gradient change of bioinspired functionally graded layer of experiment groupⅠ and experiment group Ⅱ were obtained. Conclusion The existence of bioinspired functionally graded layer can significantly reduce the stress concentration at the sub-surface of the core, and there exists optimization of elastic modulus graded change in bioinspired functionally graded layer.