Original article (Clinical research)

Gene polymorphism and linkage disequilibrium of IL-13 and IL-4 in Chinese Han population with chronic periodontitis

  • CHEN Dong ,
  • WANG Li-ming ,
  • ZHANG Jie ,
  • et al
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  • 1.Department of Periodontology, the Ninth People's Hospital, College of Stomatology, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China; 2.Department of Periodontology, Shanghai Stomatological Disease Center, Shanghai 200001, China

Online published: 2013-06-28

Supported by

Natural Science Foundation of Shanghai, 10ZR1425900; Shanghai Municipal Health Bureau Foundation, 2009202

Abstract

Objective To investigate the gene polymorphism of interleukin (IL)-13 and IL-4 in Chinese Han population with chronic periodontitis, and explore its potential relationship with chronic periodontitis. Methods Matrix-assisted laser desorption ionization time of flight mass spectrometer (MALDI-TOF-MS) was employed to detect the single nucleotide polymorphism (SNP) of rs2070874 and rs1800925 in IL-13 and rs2243248 in IL-14 in chronic periodontitis group (n=278) and healthy control group (n=324), the allele frequency and genotype distribution were calculated, and linkage disequilibrium and haplotype analysis was conducted. Results There were significant differences in the allelic frequency of rs1800925 TT genotype and T allele, as well as that of rs2243248 GG genotype and G allele between chronic periodontitis group and healthy control group (P<0.05). There were also significant differences in the distribution of rs2070874 T/rs1800925 T/rs2243248 G, rs2070874 T/rs1800925 C/rs2243248 G and rs2070874 T/rs1800925 T/rs2243248 T between two groups (P<0.05). Conclusion SNP of rs1800925 in IL-13 gene and rs2243248 in IL-4 gene may be correlated with the susceptibility to chronic periodontitis in Chinese Han population.

Cite this article

CHEN Dong , WANG Li-ming , ZHANG Jie , et al . Gene polymorphism and linkage disequilibrium of IL-13 and IL-4 in Chinese Han population with chronic periodontitis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2013 , 33(6) : 796 . DOI: 10.3969/j.issn.1674-8115.2013.06.020

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