上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (7): 861-.

• 综述 • 上一篇    下一篇

Duffy抗原趋化因子受体在炎症反应调节中的作用研究进展

齐砚庆, 综述；张 岚, 审校   

  1. 上海交通大学 医学院仁济医院血管外科, 上海 200127
  • 出版日期:2010-07-25 发布日期:2010-07-26
  • 通讯作者: 张 岚, 电子信箱: lucky200207@yahoo.com.cn。
  • 作者简介:齐砚庆（1982—）, 男, 硕士生；电子信箱: qiyanqing020434@163.com。

Research progress on roles of Duffy antigen receptor for chemokines on modulation of inflammatory reaction

QI Yan-qing, reviewer；ZHANG Lan, reviser   

  1. Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
  • Online:2010-07-25 Published:2010-07-26

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摘要：

趋化性细胞因子介导白细胞移行是炎症反应的基本方式，Duffy抗原趋化因子受体（DARC）在趋化性细胞因子的平衡和消除中具有重要的作用。内皮细胞和红细胞DARC表达的变化与多种人类炎症性和感染性疾病相关。该文就DARC的结构和分布、生物学特性及在炎症相关疾病中的作用的研究进展进行综述。

关键词: Duffy抗原趋化因子受体, 趋化因子, 炎症反应

Abstract:

The migration of leukocytes mediated by chemokines is a basic mode in inflammatory reaction, and Duffy antigen receptor for chemokines (DARC) plays an important role in the balance and elimination of chemokines. Many researches have indicated that the changes of DARC expression on endothelial cells and erythrocytes are related to many human inflammatory diseases and infectious diseases. The structure, distribution and bionomics of DARC and the research progress on roles of DARC in the inflammation-related diseases are reviewed in this paper.

Key words: Duffy antigen receptor for chemokines, chemotactic factor, inflammatory reaction