上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

琼氏不动杆菌和鲁氏不动杆菌的临床分布及耐药分析

汤荣，陈雯静，易峻文，俞琦，洪庆，舒文，刘庆中，李莉，崔泽林   

  1. 上海交通大学附属第一人民医院检验医学中心，上海 200080
  • 出版日期:2017-03-28 发布日期:2017-03-30
  • 通讯作者: 崔泽林，电子信箱：czl_phage@126.com。
  • 作者简介:汤荣（1977—），男，主管技师，学士；电子信箱：tangrong5059@126.com。
  • 基金资助:

    国家自然科学基金青年科学基金(31500154)；上海市科学技术委员会“扬帆计划”项目(15YF1409500)；上海市卫生和计划生育委员会基金（201440289）；上海交通大学附属第一人民医院“优青前计划”（06N1503012）

Antimicrobial resistances and clinical distributions of Acinetobacter junii and Acinetobacter lwoffii

TANG Rong, CHEN Wen-jing, YI Jun-wen, YU Qi, HONG Qing, SHU Wen, LIU Qing-zhong, LI Li, CUI Ze-lin   

  1. Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
  • Online:2017-03-28 Published:2017-03-30
  • Supported by:

    National Natural Science Foundation of China, 31500154；Shanghai Sailing Program from Science and Technology Commission of Shanghai Municipality, 15YF1409500; Foundation of Shanghai Health and Family Planning Committee, 201440289; Pre-outstanding Medical Youth Program of Shanghai General Hospital, 06N1503012

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摘要：

目的 ·回顾性分析上海市某三级甲等医院琼氏不动杆菌和鲁氏不动杆菌的临床分布及耐药情况，为临床防控该类菌奠定基础。方法 ·收集该院2011年8月—2016年8月琼氏不动杆菌和鲁氏不动杆菌，采用法国生物梅里埃微生物和药敏分析系统VITEK2 Compact进行细菌鉴定及药敏分析，分析其临床分布特点和耐药性。结果 ·共分离获得28株琼氏不动杆菌和58株鲁氏不动杆菌。前者样本来源主要是泌尿科、胸外科和老年科，样本种类主要是尿液和痰液，对庆大霉素、氨苄西林舒巴坦、哌拉西林、哌拉西林他唑巴坦、头孢他啶、头孢吡肟、亚胺培南、美罗培南、左氧氟沙星、环丙沙星和复方新诺明的耐药率分别为35.71%、3.57%、10.71%、3.57%、3.57%、3.57%、3.57%、3.57%、0、3.57%和35.71%；而后者样本主要来源是泌尿科、老年科、呼吸科和肾内科，样本种类主要有尿液、痰液和血液，其对上述抗生素耐药率分别为29.31%、13.79%、13.79%、6.90%、20.69%、18.97%、12.07%、15.52%、18.97%、31.03%和31.03%。5年中这2种菌的耐药率基本恒定，亚胺培南和美罗培南耐药率略有升高。结论 ·琼氏不动杆菌和鲁氏不动杆菌的耐药率较已报道的鲍曼不动杆菌低，而且琼氏不动杆菌耐药率总体较鲁氏不动杆菌耐药率低；该分析可为防控由这2种菌引起感染的经验性用药提供数据支持。

关键词: 琼氏不动杆菌, 鲁氏不动杆菌, 药敏, 临床分布

Abstract:

Objective · To analyze the clinical distribution and drug resistance of Acinetobacter junii (A. junii) and Acinetobacter lwoffii (A. lwoffii) from a grade 3A hospital in Shanghai, China, and provide the foundation for prevention and control of infections caused by them. Methods · A. junii and A. lwoffii were collected from the hospital between Aug, 2011 and Aug, 2016. VITEK2 Compact of bioMérieux (French) was used for bacterial identification and antibiotic susceptibility tests, clinical information of each strain was also analyzed. Results · 28 strains of A. junii and 58 strains of A. lwoffii were enrolled. A. junii was mainly from the departments of urology, thoracic surgery and geriatrics, and the samples were mainly sputum and urine. The resistant rates of A. junii to gentamicin, ampicillin sulbactam, piperacillin, piperacillin/tazobactam, ceftazidime, cefepime, imipenem, meropenem, levofloxacin, ciprofloxacin and cotrimoxazole were 35.71%, 3.57%, 10.71%, 3.57%, 3.57%, 3.57%, 3.57%, 3.57%, 0, 3.57% and 35.71%, respectively. A. lwoffii was mainly isolated from the departments of urology, geriatrics, respiratory and renal medicine, and the samples mainly included urine, blood and sputum. The rates of antibiotics (mentioned above) resistance were 29.31%, 13.79%, 13.79%, 6.90%, 20.69%, 18.97%, 12.07%, 15.52%, 18.97%, 31.03% and 31.03%, respectively. The levels of antibiotic resistance of these two strains were constant during the five years. Conclusion · A. junii and A. lwoffii antibiotic resistant rates were much lower than those of reported A. baumannii, the over-all antibiotic resistances of A. junii were lower than those of A. lwoffii. This study provided fundamental data for prevention or control of these two strains by empirical use of antibiotics.

Key words: Acinetobacter junii, Acinetobacter lwoffii, antimicrobial susceptibility, clinical distribution