上海交通大学学报（医学版）

上海交通大学学报（医学版）

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羧基酯脂肪酶与糖尿病和胰腺外分泌疾病相关性的研究进展

张荣，刘丽梅   

  1. 上海交通大学附属第六人民医院内分泌代谢科 上海市糖尿病研究所， 上海 200233
  • 出版日期:2015-04-28 发布日期:2015-04-29
  • 通讯作者: 刘丽梅, 电子信箱: lmliu@sjtu.edu.cn。
  • 作者简介:张荣（1988—）， 女， 硕士生; 电子信箱: zhang_rong0428@126.com。
  • 基金资助:

    国家自然科学基金(81471012, 81270876, 30771022)；上海市科委优秀学科带头人基金

Advances of carboxyl ester lipase, diabetes, and pancreatic exocrine diseases

ZHANG Rong, LIU Li-mei   

  1. Department of Endocrinology and Metabolism， Shanghai Diabetes Institute， Shanghai Sixth People's Hospital， Shanghai Jiao Tong University， Shanghai 200233， China
  • Online:2015-04-28 Published:2015-04-29
  • Supported by:

    National Natural Science Foundation of China, 81471012, 81270876, 30771022; Outstanding Academic Leaders Foundation of Science and Technology Commission of Shanghai Municipality, 10XD1403400

PDF (PC)

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摘要：

羧基酯脂肪酶(CEL)基因编码的蛋白是由胰腺腺泡细胞分泌的胆固醇酯的水解酶，是与青少年发病的成人型糖尿病（MODY）相关的7种分子中唯一非胰岛β细胞合成和分泌的蛋白。CEL基因的可变数目串联重复序列(VNTR）突变可以导致MODY-胰外分泌综合征、胰岛素依赖型糖尿病（1型糖尿病）或非胰岛素依赖型糖尿病（2型糖尿病）及酒精性胰腺炎等胰腺外分泌疾病。该文就CEL基因突变/变异与糖尿病和/或胰腺外分泌疾病相关性的研究进展进行综述。

关键词: 羧基酯脂肪酶, 青少年发病的成人型糖尿病, 胰腺外分泌疾病

Abstract:

The protein encoded by carboxyl ester lipase (CEL) gene is a kind of cholesterol ester hydrolase secreted by pancreatic acinar cells and is the only protein that is not synthesized and secreted by islet beta cells in 7 molecules relevant to the maturity-onset diabetes of the young (MODY). Mutations of the variable-number tandem repeat (VNTR) of CEL can cause the syndrome of MODY and pancreatic exocrine dysfunction, insulin-dependent diabetes mellitus (type 1 diabetes) or noninsulin-dependent diabetes mellitus (type 2 diabetes), and pancreatic exocrine diseases such as alcoholic pancreatitis. This paper reviews latest research progresses of gene mutations of CEL, diabetes, and pancreatic exocrine diseases.

Key words: carboxyl ester lipase, maturity-onset diabetes of the young, pancreatic exocrine dysfunction