上海交通大学学报（医学版）

上海交通大学学报（医学版）

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氧固醇7α羟化酶的生理作用及相关研究进展

赵轩1，孙岳平2   

  1. 上海交通大学 1.医学院2011级临床八年一贯制， 2.基础医学院生物化学与分子生物细胞学系， 上海 200025
  • 出版日期:2015-07-28 发布日期:2015-08-27
  • 通讯作者: 孙岳平, 电子信箱: jysunyp@shsmu.edu.cn。
  • 作者简介:赵轩（1993—）， 男， 本科生; 电子信箱: patrickzhao_sjtu@163.com。

Physiological functions of oxysterol 7α-hydroxylase and relevant research advances

ZHAO Xuan1, SUN Yue-ping2   

  1. 1.Eight-year-program Clinical Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2.Department of Biochemistry and Molecular Cell Biology, Basic Medicine Faculty of Shanghai Jiao Tong University, Shanghai 200025, China
  • Online:2015-07-28 Published:2015-08-27

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摘要：

氧固醇7α羟化酶（CYP7B1）是生物体内广泛分布的一类酶。CYP7B1在不同组织中通过作用于不同底物，可以产生多种生理功能，包括促进胆固醇生成胆汁酸、代谢体内冗余的氧固醇激素、调节雌激素受体介导的信号通路、调节免疫系统等。有研究表明CYP7B1的缺陷与遗传性痉挛性截瘫、先天性肝衰竭等疾病有直接联系。本文重点介绍CYP7B1的生理功能及相关的研究进展。

关键词: 氧固醇7α羟化酶, CYP7B1, 生理作用, 细胞色素P450

Abstract:

Oxysterol 7α-hydroxylase (CYP7B1) is an enzyme that widely presents in organisms and performs a variety of physiological functions including promoting the generation of bile acid from cholesterol, metabolizing excessive oxysterol hormones, regulating the signaling pathway mediated by estrogen receptor, and regulating the immune system by acting on different substrates in different tissues. Recent studies show that the defection of CYP7B1 directly correlates with spastic paraplegia type 5 (SPG5) and congenital liver failure. This paper reviews physiological functions of CYP7B1 and relevant research advances.

Key words: oxysterol 7α-hydroxylase, CYP7B1, physiological function, cytochrome P450