上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (8): 1165-.doi: 10.3969/j.issn.1674-8115.2017.08.023

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肌球蛋白调节性轻链磷酸化在慢性心力衰竭发生机制中的作用

胡珊，吴钢   

  1. 武汉大学人民医院心内科，武汉大学心血管病研究所，心血管病湖北省重点实验室，武汉 430060
  • 出版日期:2017-08-28 发布日期:2017-09-28
  • 通讯作者: 吴钢，电子信箱：wugangmd@163.com
  • 作者简介:?胡珊（1992—），女，硕士生；电子信箱：hushan221@163.com
  • 基金资助:
     国家自然科学基金（81270305，81670363）

Role of myosin regulatory light chain phosphorylation in the pathogenesis of chronic heart failure#br#

HU Shan, WU Gang   

  1. Department of Cardiology, Cardiovascular Research Institute, Hubei Key Laboratory of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
  • Online:2017-08-28 Published:2017-09-28
  • Supported by:
    National Natural Science Foundation of China, 81270305, 81670363

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摘要： 胚胎时期，肌球蛋白调节性轻链 2（myosin regulatory light chain，MYL2）在心脏的发育与功能方面扮演着重要角色。MYL2 （也称 MLC2）的基因突变与肥厚型心肌病有关。MYL2 突变可影响肌球蛋白的结构和功能，导致肥厚型心肌病、扩张型心肌病甚至慢 性心力衰竭的发生。同时，MYL2 的磷酸化在心肌收缩、心室扭转、心脏功能和疾病方面也发挥着重要作用。

关键词:  肌球蛋白调节性轻链, 慢性心力衰竭, 磷酸化, 心肌收缩

Abstract:

 In the embryonic period, myosin regulatory light chain (MYL2) plays a pivotal role in the development and function of the heart. A large number of studies have previously confirmed that the mutation of MYL2 gene, also known as MLC2, confers intimate associations with hypertrophic cardiomyopathy. MYL2 gene mutation impacts the structure and function of myosin, thereby leading to the occurrence and progression of hypertrophic and dilated cardiomyopathy as well as the following chronic heart failure. Importantly, MYL2 phosphorylation renders crucial effects in the processes of cardiac contraction, ventricular torsion and cardiac function.

Key words: myosin regulatory light chain, chronic heart failure, phosphorylation, myocardial contractility