上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (12): 1670-.doi: 10.3969/j.issn.1674-8115.2017.12.016

• 论著（临床研究） • 上一篇    下一篇

绝经前后子宫内膜癌的临床及病理特征分析

刘华，建方方，宋玮，沈立翡   

  1. 上海交通大学 医学院附属瑞金医院妇产科，上海  200025
  • 出版日期:2017-12-28 发布日期:2018-01-10
  • 通讯作者: 沈立翡，电子信箱：slf10438@rjh.com.cn
  • 作者简介:刘华（1978—），女，副主任医师，博士；电子信箱：lh11239@rjh.com.cn

Clinical and pathological characteristics of endometrial carcinoma in premenopausal and  postmenopausal patients#br#

LIU Hua, JIAN Fang-fang, SONG Wei, SHEN Li-fei   

  1. Department of Obstetrics and Gynecology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2017-12-28 Published:2018-01-10

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摘要： 目的 · 分析绝经前后子宫内膜癌患者的临床及病理特点。方法 · 回顾性分析2013 年 12 月—2017 年 3 月上海交通大学医学 院附属瑞金医院52 例绝经前和 150 例已绝经子宫内膜癌患者的临床病理资料。结果 · 未绝经组合并高血压比例为28.8%，显著低于 绝经组（P<0.01）；未绝经组的组织学分级G3 比例为8.3%，伴深肌层浸润比例为13.5%，均显著低于绝经组（P<0.05）；未绝经组 累及卵巢比例高达17.6%，显著高于绝经组（P<0.05）。 2 组病例在合并肥胖或糖尿病、CA125、CA199、手术- 病理分期、病理类 型、脉管浸润、淋巴结转移等方面差异无统计学意义。结论 · 未绝经的子宫内膜癌患者肿瘤恶性程度相对较低，但累及卵巢的概率 更大。

关键词: &ensp, 子宫内膜癌；未绝经；绝经；临床病理特征

Abstract:

Objective · To analyze the clinical and pathological characteristics of endometrial carcinoma patients before and after menopause.  Methods · Fifty-two premenopausal cases and 150 postmenopausal cases with endometrial carcinoma from December 2013 to March 2017 in Ruijin Hospital, Shanghai Jiao Tong University School of Medicine were retrospectively analyzed.   Results · The ratio of patients with hypertension in premenopausal group was 28.8%, which was significantly lower than that in postmenopausal group (P<0.01). In premenopausal group, the proportion of G3 in histological grading was 8.3%, and the ratio of deep myometrial invasion was 13.5%, all of which were significantly lower than those of postmenopausal group (P<0.05). The ratio of ovarian involvement was as high as 17.6%, which was significantly higher than that of postmenopausal group (P<0.05). There were no significant differences between the two groups in other clinical-pathological parameters such as obesity, diabetes, CA125, CA199, surgical-pathological staging, pathological type, vascular involvement, and lymph node metastasis.  Conclusion · Premenopausal endometrial carcinoma is less malignant, while the probability of ovarian involvement is higher.

Key words: endometrial carcinoma, premenopause, postmenopause, clinical-pathological characteristic