上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (5): 550-.doi: 10.3969/j.issn.1674-8115.2019.05.021

• 综述 • 上一篇    

大气细颗粒物暴露致发育毒性研究进展

任云杰 1，施烨闻 2，王广鹤 1   

  1. 1. 上海交通大学公共卫生学院，上海 200025；2. 上海市疾病预防控制中心环境卫生科，上海 200336
  • 出版日期:2019-05-28 发布日期:2019-07-26
  • 通讯作者: 王广鹤，电子信箱：ghewang@shsmu.edu.cn。
  • 作者简介:任云杰（1995—），女，本科生；电子信箱： 2889671295@qq.com。
  • 基金资助:
    国家自然科学基金（81502778）

Developmental toxicity of exposure to ambient fine particulate matter

REN Yun-jie1, SHI Ye-wen2, WANG Guang-he1   

  1. 1. Shanghai Jiao Tong University School of Public Health, Shanghai 200025, China; 2. Department of Environmental Health, Shanghai Center for Disease Control and Prevention, Shanghai 200336, China
  • Online:2019-05-28 Published:2019-07-26
  • Supported by:
    National Natural Science Foundation of China, 81502778

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摘要： 国内外研究表明细颗粒物（particulate matter 2.5，PM2.5）污染是影响人体健康的重要因素。除了直接对呼吸系统及心血管系统的影响外，妊娠期 PM2.5暴露可直接影响子代的生长发育，表现为心肺功能及认知功能受损、各种不良妊娠结局、器官发育异常、先天缺陷等问题，但 PM2.5致发育毒性的作用机制尚不明确。该文对 PM2.5致发育毒性的流行病学及毒理学研究进展进行综述，以期为后续的研究提供参考依据。

关键词: 大气细颗粒物, 妊娠期暴露, 毒理学研究, 流行病学调查, 发育毒性, 毒性机制

Abstract:

Domestic and foreign studies have shown that fine particulate matter (PM2.5) pollution is a major factor affecting human health. In addition to the direct impact on the respiratory and cardiovascular systems, PM2.5 exposure during pregnancy can directly affect the growth and development of offspring, manifested as cardiopulmonary dysfunction and cognitive disorder, various adverse pregnancy outcomes, abnormal organ development, and congenital defects. However, the mechanism underlying the developmental toxicity of PM2.5 is still unclear. This article reviews PM2.5-induced developmental toxicity based on epidemiological investigation and toxicological studies, which will provide references for further studies.

Key words: ambient fine particulate matter, pregnancy exposure, toxicological study, epidemiological investigation, developmental toxicity, toxic mechanism

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