上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (12): 1632-1636.doi: 10.3969/j.issn.1674-8115.2020.12.011

• 论著·临床研究 • 上一篇    下一篇

种植体周围炎龈沟液中IL-1β、IL-6和TNF-α的表达

陈慧文1，胡 苡1，张卫平2，陈景宜2#，宋忠臣1#   

  1. 1. 上海交通大学医学院附属第九人民医院·口腔医学院牙周病科，国家口腔疾病临床研究中心，上海市口腔医学重点实验室，上海市口腔医学研究所，上海 200011；2. 甘肃省兰州市口腔医院，兰州 730000
  • 出版日期:2020-12-28 发布日期:2021-02-02
  • 通讯作者: 陈景宜，电子信箱：316715771@qq.com。宋忠臣，电子信箱：szhongchen@sina.com。#为共同通信作者。
  • 作者简介:陈慧文（1991—），女，住院医师，硕士；电子信箱：chenhuiwen1220@126.com。
  • 基金资助:
    兰州市人才创新科技计划（2017-RC-12）。

Expression of IL-1β, IL-6 and TNF-α in sulcular fluid of peri-implantitis

CHEN Hui-wen1, HU Yi 1, ZHANG Wei-ping2, CHEN Jing-yi2#, SONG Zhong-chen1#   

  1. 1. Department of Periodontology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China; 2. Stomatology Hospital of Lanzhou City, Gansu Province, Lanzhou 730000, China
  • Online:2020-12-28 Published:2021-02-02
  • Supported by:
    Lanzhou Talent Innovation Science and Technology Plan (2017-RC-12).

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摘要： 目的·检测白介素（interleukin，IL） -1β、IL-6和肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）在种植体周围炎患者龈沟液中的表达并分析其临床意义。方法·选择因牙列缺损行种植修复的患者24例，其中种植周围炎组患者12例，种植体周围组织健康组12例；另选择12名具健康天然牙的健康者为对照组。收集3组患者龈沟液，采用酶联免疫吸附法检测龈沟液中IL-1β、IL-6和TNF-α含量，分析其表达水平与龈沟液量和牙周探诊深度的相关性。结果·种植体周围炎组患者IL-1β、IL-6和TNF-α明显高于对照组（均P<0.05），且种植体周围炎组IL-1β和IL-6表达水平显著高于种植体周围组织健康组（均P<0.05）；其中种植体周围炎组龈沟液中TNF-α表达水平与探诊深度呈正相关（r=0.600，P=0.039）。结论·种植体周围炎患者龈沟液中IL-1β、IL-6和TNF-α表达升高，且TNF-α表达水平与探诊深度呈正相关。

关键词: 种植体周围炎, 龈沟液, 白介素-1β, 白介素-6, 肿瘤坏死因子-α

Abstract:

Objective · To investigate expressions of interleukin (IL) -1β, IL-6 and tumor necrosis factor-α (TNF-α) in sulcular fluid of peri-implantitis. Methods · Twenty-four patients with implant restoration were selected, including 12 patients in the peri-implantitis group and 12 patients in the peri-implant health group. Twelve healthy persons with healthy gingival tissues were taken as the control group. The levels of IL-1β, IL-6 and TNF-α in gingival crevicular fluid were detected by enzyme-linked immunosorbent assay. The correlations between the expressions of these cytokines and the amount of gingival crevicular fluid or the probing depth were analyzed. Results · The levels of IL-1β, IL-6 and TNF-α in the peri-implantitis group were significantly higher than those in the control group (all P<0.05). The expression levels of IL-1β and IL-6 in the peri-implantitis group were significantly higher than those in the peri-implant health group (both P<0.05). The level of TNF-α in the peri-implantitis group was positively correlated with the probing depth (r=0.600, P=0.039). Conclusion · The levels of IL-1β, IL-6 and TNF-α in gingival crevicular fluid are highly expressed in patients with peri-implantitis. The expression of TNF-α is positively correlated with the probing depth.

Key words: peri-implantitis, gingival crevicular fluid, interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)

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