鼻息肉组织中CD68的表达及与微血管密度的关系
网络出版日期: 2013-06-28
Expression of CD68 and its relationship with microvessel density in tissues of nasal polyps
Online published: 2013-06-28
目的 观察慢性鼻窦炎鼻息肉(CRSwNP)患者鼻息肉组织中巨噬细胞表面抗原CD68的表达及微血管密度(MVD),并分析两者的相关性。方法 采用免疫组织化学染色SP法检测73例CRSwNP患者(CRSwNP组)鼻息肉组织中CD68的表达和MVD,以无CRSwNP及变应性疾病史的30例鼻中隔偏曲患者作为对照组。对CRSwNP组患者鼻息肉组织中CD68的表达与MVD进行相关性分析。结果 免疫组织化学染色结果显示,CRSwNP组鼻息肉组织中CD68的表达强度和MVD均显著高于对照组鼻中隔黏膜组织(P<0.01)。CRSwNP患者鼻息肉组织中CD68的表达强度与MVD呈显著正相关(r=0.871,P<0.01)。结论 CRSwNP的发生和发展可能与巨噬细胞活化及微血管增生有关。
吴继昌 , 王士礼 , 蔡昌枰 . 鼻息肉组织中CD68的表达及与微血管密度的关系[J]. 上海交通大学学报(医学版), 2013 , 33(6) : 838 . DOI: 10.3969/j.issn.1674-8115.2013.06.028
Objective To detect the expression of macrophage surface antigen CD68 and microvessel density (MVD) in tissues of nasal polyps in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), and explore their correlation. Methods The expression of CD68 and MVD in tissues of nasal polyps in 73 patients with CRSwNP (CRSwNP group) were determined by immunohistochemistry SP method, and 30 patients having nasal septal deviation without CRSwNP and history of allergic diseases were served as control group. The correlation of expression of CD68 with MVD in tissues of nasal polyps in CRSwNP group was explored. Results Immunohistochemical staining revealed that the expression of CD68 and MVD in tissues of nasal polyps in CRSwNP group were significantly higher than those in nasal septal mucosa in control group (P<0.01). There was a significantly positive correlation between the expression of CD68 and MVD in tissues of nasal polyps in CRSwNP group (r=0.871, P<0.01). Conclusion The development of CRSwNP may be associated with the activation of macrophages and angiogenesis.
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