外泌体及其在干细胞中的研究进展
网络出版日期: 2013-06-28
基金资助
国家自然科学基金(81170640,81272170)
Research progress of exosomes in stem cells
Online published: 2013-06-28
Supported by
National Natural Science Foundation of China,81170640,81272170
胡国文 , 汪 泱 , 沈晓黎 , 等 . 外泌体及其在干细胞中的研究进展[J]. 上海交通大学学报(医学版), 2013 , 33(6) : 868 . DOI: 10.3969/j.issn.1674-8115.2013.06.034
Exosomes are small secreted vesicles, which play key roles in cell-to-cell communication. Exosomes can be released by different types of cells, and help to exchange membrane and transfer proteins, mRNA, microRNA and organelles between cells. Exosomes modulate normal physiological processes by transforming gene regulatory network or epigenetic reorganization. Recent studies have found that exosomes secreted by stem cells can transport mRNA, microRNA and proteins effectively, and play an important role in regulating tissue regeneration. The generation of exosomes and the research progress of exosomes in stem cells are reviewed in this paper.
Key words: exosome; stem cells; regenerative medicine
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