自然绝经年龄相关候选基因的研究进展
Research progress of candidate gene of age at natural menopause
Online published: 2013-06-28
孙东梅 , 陶敏芳 . 自然绝经年龄相关候选基因的研究进展[J]. 上海交通大学学报(医学版), 2013 , 33(6) : 874 . DOI: 10.3969/j.issn.1674-8115.2013.06.035
Age at natural menopause (ANM) is a complex trait which is determined by genes and environment, and the genetic effects are prominent. Early or delayed menopause is associated with female-related diseases. Exploring genetic factors of ANM can help to predict the potential health problems of postmenopausal women, and may provide appropriate health guidance. It has been found by genome-wide association studies and candidate gene association studies that several genes are associated with ANM. The research progress of candidate genes of ANM is reviewed in this paper.
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