综述

自然绝经年龄相关候选基因的研究进展

  • 孙东梅 ,
  • 陶敏芳
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  • 上海交通大学附属第六人民医院妇产科, 上海 200233
孙东梅(1986—), 女, 硕士生; 电子信箱: sdcxsdm@163.com。

网络出版日期: 2013-06-28

Research progress of candidate gene of age at natural menopause

  • SUN Dong-mei ,
  • TAO Min-fang
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  • Department of Obstetrics and Gynecology, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China

Online published: 2013-06-28

摘要

自然绝经年龄(ANM)是受基因与环境共同影响的复杂性状,其中基因影响较为突出。绝经年龄的提前或延迟与女性相关疾病有关。探讨基因作用对ANM的影响,有助于预测绝经后女性潜在的健康问题,并可为女性提供相关的健康指导。目前,全基因组关联研究及候选基因关联分析已发现数个基因与之相关,该文就ANM相关基因的研究进展予以综述。

本文引用格式

孙东梅 , 陶敏芳 . 自然绝经年龄相关候选基因的研究进展[J]. 上海交通大学学报(医学版), 2013 , 33(6) : 874 . DOI: 10.3969/j.issn.1674-8115.2013.06.035

Abstract

Age at natural menopause (ANM) is a complex trait which is determined by genes and environment, and the genetic effects are prominent. Early or delayed menopause is associated with female-related diseases. Exploring genetic factors of ANM can help to predict the potential health problems of postmenopausal women, and may provide appropriate health guidance. It has been found by genome-wide association studies and candidate gene association studies that several genes are associated with ANM. The research progress of candidate genes of ANM is reviewed in this paper.

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