综述

抑癌基因PTEN对细胞增生的调控机制

  • 熊 忠 ,
  • 陈国强
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  • 上海交通大学 1.医学院附属瑞金医院细胞分化与凋亡教育部重点实验室, 2.基础医学院病理生理学教研室, 上海 200025
熊忠(1984—), 男, 硕士生; 电子信箱: xiongzhong2009@yahoo.com.cn。

网络出版日期: 2013-06-28

Cellular proliferation regulations by tumor suppressor gene PTEN

  • XIONG Zhong ,
  • CHEN Guo-qiang
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  • 1.Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China; 2.Department of Pathophysiology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China

Online published: 2013-06-28

摘要

人第10号染色体缺失的磷酸酶及张力蛋白同源的基因(PTEN)是近年来研究较多的抑癌基因,与肿瘤的关系极其密切。PTEN的异常导致PI3K-AKT信号通路活化是其引起癌症发生的主要机制。因此,关于PTEN调控机制的研究对于揭示其新的致病机制和寻找新的治疗方案有着十分重要的意义。该文主要就PTEN在转录以及转录后调控、蛋白质翻译后修饰和蛋白之间相互作用等方面进行了论述,阐述了其在细胞中被调控的机制。

本文引用格式

熊 忠 , 陈国强 . 抑癌基因PTEN对细胞增生的调控机制[J]. 上海交通大学学报(医学版), 2013 , 33(6) : 878 . DOI: 10.3969/j.issn.1674-8115.2013.06.036

Abstract

Phosphatase and tensin homolog deleted on chromosome ten (PTEN), one of the mostly investigated tumor suppressor genes, has a close correlation with tumorigenesis. The activation of PI3K-AKT pathway caused by abnormal PTEN is one of the major mechanisms underlying tumor occurrence. Therefore, PTEN regulation is important for uncovering new mechanisms of tumor occurrence and establishing novel therapeutic strategies. The cellular PTEN regulations including transcriptional regulation, post-transcriptional modulation, post-translation modification and protein-protein interaction are reviewed in this paper.

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