论著(临床研究)

糖尿病视网膜病变患者血清转化生长因子β水平研究

  • 罗大卫 ,
  • 郑 志 ,
  • 刘 堃 ,
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  • 上海交通大学附属第一人民医院眼科, 上海 200080
罗大卫(1977—),男,主治医师,硕士; 电子信箱: dr-davie@yeah.net。

网络出版日期: 2013-08-22

基金资助

上海市眼底病重点实验室开放课题基金(07Z22911)

Serum transforming growth factor-β levels in patients with diabetic retinopathy

  • LUO Da-wei ,
  • ZHENG Zhi ,
  • LIU Kun ,
  • et al
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  • Department of Ophthalmology, the First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China

Online published: 2013-08-22

Supported by

Shanghai Key Laboratory for Ocular Fundus Disease Foundation, 07Z22911

摘要

目的 探讨糖尿病视网膜病变患者血清转化生长因子β(TGF-β)水平变化。方法 72例糖尿病患者分为增生性糖尿病视网膜病变组(PDR组,n=15)、非增生性糖尿病视网膜病变组(NPDR组,n=32)和无糖尿病视网膜病变组(NDR组,n=25) ;以45名体检健康者作为正常对照组。采用酶联免疫吸附法测定各组血清TGF-β水平。结果 糖尿病患者TGF-β水平显著高于正常对照组(P<0.01),PDR组血清TGF-β水平显著高于NPDR组和NDR组(P<0.05)。结论 TGF-β水平与糖尿病视网膜病变的病变程度密切相关。

本文引用格式

罗大卫 , 郑 志 , 刘 堃 , . 糖尿病视网膜病变患者血清转化生长因子β水平研究[J]. 上海交通大学学报(医学版), 2013 , 33(7) : 990 . DOI: 10.3969/j.issn.1674-8115.2013.07.019

Abstract

Objective To investigate the serum transforming growth factor-β (TGF-β) levels in patients with diabetic retinopathy  (DR). Methods Seventy-two patients with diabetes were selected, including 15 patients with proliferative diabetic retinopathy (PDR group), 32 patients with non-proliferative diabetic retinopathy (NPDR group) and 25 patients with non-diabetic retinopathy group (NDR group). Besides, 45 healthy people were served as normal control group. The serum TGF-β levels were detected by ELISA. Results Serum TGF-β levels in groups with diabetes were significantly higher than that in normal control group (P<0.01). Serum TGF-β level in PDR group was significantly higher than those in NPDR group and NDR group (P<0.05). Conclusion Serum TGF-β level is associated with the severity of diabetic retinopathy.

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